Project Grant R35GM163680
- The National Science Foundation Division of Molecular and Cellular Biosciences awarded the University of Illinois $763,130 on June 1, 2026, under the Biological Sciences program (CFDA 47.074) to decode active and passive mechanisms driving bacterial chromosome dynamics. The project combines high-resolution single-molecule tracking, MINFLUX super-resolution microscopy, quantitative polymer-physics modeling, and in vitro reconstitution to measure fast-timescale motion of genomic loci in the...
- The National Institute of General Medical Sciences awarded the University of Illinois $2,101,232 on August 10, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop quantitative computational approaches that probe diverse biological processes and relate their outcomes to molecular structure and motion. The project will develop computational methods ranging from atomistic molecular dynamics to continuum simulations, guided by unmet needs in basic biomedical...
- The National Institute of General Medical Sciences awarded the University of Illinois $372,016 on July 7, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to deconstruct RNA polymerase III regulation and function through systematic profiling of POL III activity and discovery of new regulatory mechanisms. The research applies genomic and biochemical strategies to characterize POL III transcription breadth and tissue-specific patterns, focusing initially on the...
- The National Institute of General Medical Sciences awarded The University of Chicago $125,820 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to integrate evolutionary history and biophysics toward combating antibiotic resistance through study of bacterial Na+/H+ antiporters and related proton-coupled transporters. The research targets Na+/H+ antiporters, a diverse family of membrane proteins essential to bacterial stress resistance and virulence...
- The National Institute of General Medical Sciences awarded the University of Illinois $303,685 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to discover and characterize RIPP biosynthetic enzymes. The work focuses on assigning catalytic function to domains of unknown function (DUFs) encoded in microbial genomes, particularly those involved in ribosomally synthesized and posttranslationally modified peptides (RIPPs) biosynthesis. The research...
- The National Institute of Allergy and Infectious Diseases awarded the University of Illinois $236,407 on September 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the structural basis of ARMA-mediated resistance to aminoglycoside antibiotics targeting the bacterial ribosome. The research addresses how ARMA methyltransferases confer high-level resistance to aminoglycosides—a cornerstone class of ribosome-binding antibacterial drugs used...
- The National Institute of General Medical Sciences awarded Northwestern University $428,064 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct experimental and theoretical analysis of principles underlying molecular and genomic mechanobiology. The funded research examines chromosome structure and dynamics using cell- and molecule-scale mechanics combined with genetic, biochemical, single-molecule, and mathematical modeling approaches. The...
- The National Institute of General Medical Sciences awarded The University of Chicago $602,095 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the structure and function of molecular machines involved in protein and RNA modifications. Over the five-year performance period ending June 30, 2031, the laboratory will conduct integrated structural and biochemical studies of three interconnected systems: the ubiquitin-proteasome pathway...
- The National Institute of General Medical Sciences awarded The University of Chicago $444,788 on May 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate piRNA-based immunity mechanisms in germ cells across developmental and spatial dimensions. The research examines how germ cells distinguish self from non-self RNAs to protect genome integrity across generations, focusing on small RNA pathways and germ granules in C. elegans germline biology. The work...
- The National Institute of General Medical Sciences awarded the Board of Trustees of Illinois State University $148,000 on August 3, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate how polyphosphate protects gram-negative bacteria from membrane stress and to examine the impact of pharmacological PPK1 inhibition on biofilm-associated bacteria. The project, titled "Bacterial Responses to Stress—Polyphosphate," will run through May 31, 2030,...
The National Institute of General Medical Sciences awarded the University of Illinois $420,618 on August 13, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support research on structural and functional vulnerabilities of the bacterial chromosome. The research addresses three phenomena in Escherichia coli: catastrophic chromosome fragmentation induced by potentiated oxidative damage, R-lesions (toxic RNA contaminations of DNA structure), and thymineless death. The work aims to identify conditions that damage bacterial chromosomes beyond repair capacity, with applications to antibacterial treatment development. The investigator will employ complementary analytical approaches, including identifying dramatic physical readouts for each phenomenon, establishing and cross-referencing mutant phenotypes with physical readouts, and profiling dying-cell chromosomes from a genome perspective using DNA copy-number and structural analysis. The award supports performance at the University of Illinois in Urbana, Illinois, with a period of performance through May 31, 2031. The assistance type is a Project Grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $420.6k | 8/12/26 |