This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), aims to investigate the contribution of noncoding tandem repeat expansions to the etiology of Autism Spectrum Disorder (ASD). The $188,393 award, granted to the University of Nevada, Las Vegas, will fund a 4-year research project to: 1) identify high-confidence ASD-risk genes with tandem repeat expansions, 2) select tandem repeat expansions based on their potential to disrupt ASD-risk gene transcript processing, and 3) test the hypothesis that intronic tandem repeat expansions alter specific regulatory steps during ASD-risk gene RNA processing. The project seeks to provide a new approach to identify ASD-risk genes from underpowered studies, develop criteria to estimate the propensity of tandem repeat expansions to perturb ASD-risk gene expression, and bridge the gap between genomic findings and their mechanistic basis in ASD. The award also aims to provide research opportunities for underrepresented students and strengthen the recipient's research environment.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $188.4k | 8/14/24 |