Project Grant R16GM153640
Award Date
6/13/24
Completion Date
5/31/28
Dollars Obligated
$147K
Federal Agency
National Institute of General Medical Sciences
Federal Grant Program
93.859
Assistance Type
Project Grant
Place of Performance
San Jose, CA 95192, USA
Similar Awards
This $360,100 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to elucidate biological mechanisms for proton transfer. The goal is to design photoacid-binding proteins that can spectroscopically study proton dynamics in biological systems. The research will leverage computational protein design tools to position photoacid cofactors within designer protein scaffolds to...
The National Institute of General Medical Sciences (NIGMS) awarded a 5-year, $777,018 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to the University of California, Berkeley. The grant, effective September 1, 2024, will support research to identify the mechanisms by which calcium ion (Ca2+) signaling encodes and decodes information in plant cells, with the goal of advancing the conceptual understanding of Ca2+ signaling, which has broad relevance to human health. The...
This $125,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to define the mechanisms governing the stability of the MYC family of transcription factors and how they are modulated by the Aurora Kinase A protein. The goal is to structurally characterize the C-MYC/Aurora Kinase A complex using techniques like X-ray crystallography and cryo-electron microscopy, and to further...
This $378,750 federal Project Grant award was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) to Saint Louis University. The objective of this 3-year project, which runs from September 2024 through August 2027, is to study the function and regulation of YCX1, a newly discovered protein required for proper calcium signaling in yeast. The research aims to characterize YCX1's biochemical activity,...
This $440,000 five-year (2025-2029) Project Grant award from the National Institute of General Medical Sciences (CFDA 93.859 Biomedical Research and Research Training program) supports research to advance the understanding of ubiquitin and autophagy signaling networks, which are essential cellular processes involved in proteome homeostasis. The research team at the Sloan-Kettering Institute for Cancer Research in New York will utilize their expertise in quantitative mass spectrometry,...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $810,000.00 in funding to The University of Texas MD Anderson Cancer Center to conduct a functional analysis of arginine methylation, a common post-translational modification. The research aims to broadly understand the biological roles of arginine methylation, including characterizing a novel reader protein called SART3 and...
The National Institute of General Medical Sciences (NIGMS) awarded a $147,500 Project Grant under the Biomedical Research and Research Training Program (CFDA 93.859) to The University Corporation in Northridge, CA. The grant funds a 4-year research project focused on determining the structural determinants and thermodynamic landscapes for G protein coupling and activation in G Protein-Coupled Receptor (GPCR) signaling pathways. The project leverages computational approaches and experimental...
This Project Grant award of $380,540 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) supports research to decipher novel principles of rapid proteostatic control and develop innovative spatiotemporal lysosomal tools. The research aims to define novel protein substrates and peptide motifs required for lysosomal delivery, determine the functional impact of rapid methyl-driven lysosomal proteolysis as a...
The National Institute of General Medical Sciences (NIGMS) awarded a $540,514 Project Grant under the Biomedical Research and Research Training Program (CFDA 93.859) to the University of Maryland Baltimore County (UMBC). The grant, effective July 1, 2024 through March 31, 2029, supports research to uncover how the adapter protein NDRG1 regulates cellular adaptation to fluctuations in oxygen levels. Specifically, the project aims to investigate how NDRG1 controls the trafficking of the...
This $469,500 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research on cell-cell signaling and pattern formation in the yeast Saccharomyces cerevisiae. The research aims to determine the role of signaling pathways, transcription factors, and secreted metabolites in regulating how yeast colonies adapt to their environment through changes in the relative proportions of different cell...