Project Grant R35GM153387

This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $810,000.00 to the University of Texas MD Anderson Cancer Center to conduct a functional analysis of arginine methylation, a common post-translational protein modification. The goal is to broadly understand the biological roles of arginine methylation, including characterizing a novel reader protein called SART3 and investigating the functions of two known arginine methylation effectors, SND1 and TDRD3. The research activities will employ a combination of mouse studies and protein array analyses, with the aim of elucidating new signaling pathways and mechanisms involving arginine methylation. The award period runs from September 1, 2024 to July 31, 2029.