Project Grant R56DE036303
- The National Institute of Dental and Craniofacial Research awarded the Stowers Institute For Medical Research $371,250 on March 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate the pathogenesis, phenotypic variation, and prevention of craniofacial anomalies. The project examines how genetic and environmental factors interact to produce craniofacial birth defects—conditions such as cleft lip and palate, micrognathia, and craniosynostosis that account...
- The National Institute of Dental and Craniofacial Research, part of the Department of Health and Human Services National Institutes of Health, awarded $128,191 to the University of California Irvine on May 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121). The award supports a project grant (K99DE034828) to identify non-coding genetic sources of mammalian craniofacial variation and test their functional impact on facial morphogenesis. The research addresses the...
- The National Institute of Dental and Craniofacial Research awarded the Stowers Institute for Medical Research $124,200 on September 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate ribosome biogenesis regulation of neural crest cell differentiation in development and disease. The funded research examines how ribosomal RNA transcription and ribosome biogenesis control neural crest cell fate acquisition and differentiation during craniofacial...
- The National Institute of Dental and Craniofacial Research, part of the Department of Health and Human Services National Institutes of Health, awarded $151,590 to The Johns Hopkins University on February 18, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to support research determining the role of RAFTLIN-2 in neural crest cell specification and migration. The research investigates how RAFTLIN-2, a gene upregulated during cranial neural crest cell specification,...
- The National Institute of Dental and Craniofacial Research awarded the University of New Mexico $305,000 under the Oral Diseases and Disorders Research program (CFDA 93.121) on June 5, 2026. The award funds research into the mechanisms by which PRDM3 and PRDM16 chromatin modifiers control craniofacial cartilage development. The research uses genetic mouse models, in vitro cell culture systems, and molecular tools to test whether precise levels of these paralogs fine-tune Wnt/β-catenin...
- The National Institute of Dental and Craniofacial Research, part of the Department of Health and Human Services National Institutes of Health, awarded the University of Illinois $249,000 on August 5, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to develop bone-like organoids that elucidate how immune responses influence craniofacial bone healing and regeneration. The recipient will establish bone-like organoids as predictive tools for craniofacial bone repair...
- The National Institute of Dental and Craniofacial Research awarded the University of New Hampshire $299,950 on August 19, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to develop a functional smoothed deep learning approach combining deep neural networks and functional data analysis techniques for analyzing high-dimensional genetic data associated with orofacial clefts and predicting disease risk. The research will build and validate a functional smoothed deep...
- The National Institute of Dental and Craniofacial Research awarded the University of California, Davis $301,086 on July 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate cyclooxygenase signaling in neural crest migration and craniofacial development. The research identifies the role of cyclooxygenase (COX) signaling in regulating neural crest epithelial-to-mesenchymal transition, migration, and differentiation during embryonic development. The work...
- The National Institute of Dental and Craniofacial Research awarded the University of Southern California $675,063 on September 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to support research deciphering the conserved grammar of craniofacial enhancer function. The recipient will use the funding to investigate how mutations in gene regulatory elements (enhancers) lead to congenital craniofacial anomalies. The research employs two complementary approaches:...
- The National Institute of Dental and Craniofacial Research awarded The Leland Stanford Junior University $161,220 on September 30, 2025, under the Oral Diseases and Disorders Research program (CFDA 93.121). The recipient will conduct research deciphering transcription factor spatiotemporal and dosage effects in face development. The study uses SOX9 as a model to determine how changes in transcription factor expression directly link to gene regulation and translate into facial morphological...
The National Institute of Dental and Craniofacial Research awarded the University of Texas Health Science Center at Houston $400,000 on August 24, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121, assistance type: Project Grant R56DE036303). The recipient will investigate the function of TWIST1 and its regulatory pathway in craniofacial bone development, focusing on the genetic interaction between the epithelial-to-mesenchymal transition transcription factor TWIST1 and interferon regulatory factor 6 (IRF6). Research includes functional studies in mouse models to elucidate how TWIST1 and IRF6 interact during craniofacial formation, the role of TWIST1 in cranial neural crest cells (CNCs) during migration and bone development, and the effects of TWIST1 phosphorylation on CNC-derived craniofacial defects. The work aims to enhance risk assessment of craniofacial birth defects and support development of targeted therapies for congenital cleft lip and palate and related syndromic disorders. Work is performed in Houston, Texas. The period of performance runs from August 24, 2026, through August 23, 2027. The Oral Diseases and Disorders Research program supports basic, translational, and clinical research in dental, oral, and craniofacial health and disease to advance prevention, early detection, and treatment strategies.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $400.0k | 8/26/26 |