Project Grant R16AI189452
- The National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), awarded a $133,223 Project Grant to the University of Washington to characterize host proteins that restrict Zika virus (ZIKV). The project aims to identify host genes, including both interferon-stimulated genes and non-interferon-stimulated genes, that contribute to the innate immune system's ability to restrict ZIKV replication in human...
- This $116,766 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research at Rutgers, The State University to define the long-term neurological consequences of asymptomatic Zika virus (ZIKV) infection. The research team has developed an immunocompetent mouse model of systemic ZIKV infection in which infected animals do not display...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $530,385.00 to the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University to conduct research on how host cell factors regulate the activity of the essential flaviviral enzyme NS3 in viral pathogens like dengue, Zika, and West Nile viruses. The research aims to define in detail how...
- The Project Grant award of $449,625.00 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research (CFDA 93.855) program aims to develop a novel mouse model of arthropod-borne virus (ABV) transmission. The model will co-engraft a functional human immune system and human skin organoids to better understand the human cutaneous responses to ABV transmission, which is critical for developing effective antiviral countermeasures. This...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research investigating the role of the MERTK receptor tyrosine kinase in cognitive and behavioral dysfunction in mice with congenital Zika virus infection. The $234,359 award, effective from January 15, 2025 through December 31, 2029, will enable researchers at the Washington...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $781,718 Project Grant through its Allergy and Infectious Diseases Research program (CFDA 93.855) to Loyola University of Chicago to develop a novel T cell-based vaccine to prevent Dengue and Zika virus infections. The 5-year project aims to create a vaccine that induces cytotoxic T cells targeting the Zika virus non-structural protein 3, without causing antibody-dependent enhancement observed with vaccines targeting the...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $808,919 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Trustees of Boston University. The 5-year grant, which began on September 18, 2025, aims to develop novel aglain derivatives as host-targeted antivirals against dengue virus (DENV) and other mosquito-borne arboviruses. The research program seeks to optimize the aglain chemical series and study their modulation of the host...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), will support research to decipher the role of the chemokine receptor CCR5 in protecting against flavivirus infections during pregnancy. The $3,021,038 grant, awarded on September 2, 2025, will fund a study to investigate the mechanisms by which CCR5 provides neuroprotection against West Nile virus, Zika virus, and other...
- This Project Grant award of $2,536,503 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to understand how the ability of Aedes aegypti mosquitoes to tolerate desiccation affects their potential as disease vectors. The research aims to identify genetic mechanisms linking desiccation tolerance to susceptibility to Zika, Chikungunya, and Dengue viruses in the mosquito midgut. Key...
- This Project Grant award of $699,339.00 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to study the transmission dynamics of dengue and Zika viruses across diverse communities in northwestern coastal Ecuador. The study aims to characterize how changes in environment, social networks, and vector populations influence regional virus transmission patterns. Key activities include...
This Project Grant award of $154,500 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) aims to unravel the mechanisms behind Zika virus (ZIKV)-induced cardiac dysfunction in a mouse model. The overarching objective is to deepen the understanding of viral heart disease pathogenesis and identify novel therapeutic targets. The award will fund in vitro and in vivo investigations to explore the impact of ZIKV replication on cardiomyocyte function, gap junction conductance, and inflammation. Findings from this research could inform the development of effective interventions for ZIKV-associated cardiac abnormalities, particularly in pediatric patients. The award period runs from August 13, 2025 to July 31, 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $154.5k | 9/9/25 |