This federal Project Grant award of $429,000.00, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to examine chromatin architecture and gene regulatory networks in Anopheles coluzzii mosquito hemocyte cells. The key objectives are to 1) map chromatin architecture during immune activation in mosquito hemocyte cells, and 2) identify gene regulatory networks for the immune...
This Project Grant award of $699,339.00 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to study the transmission dynamics of dengue and Zika viruses across diverse communities in northwestern coastal Ecuador. The study aims to characterize how changes in environment, social networks, and vector populations influence regional virus transmission patterns. Key activities include...
This $505,238 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) will support research to identify skin-associated compounds that can disrupt mosquito landing and biting behavior. The overarching goal is to discover new chemical compounds that can act as improved topical insect repellents compared to DEET, especially for use in tropical regions. The research will involve validating...
This $588,514 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) aims to develop new tools for improving mosquito population suppression technologies in Aedes aegypti, a key disease vector. The key focus areas include: Evaluating conditional and sex-specific lethal systems that can restrict lethal transgene expression to reduce fitness load on the mosquito population. This includes...
This Project Grant award of $699,814 from the National Institute of Allergy and Infectious Diseases (NIAID) under CFDA 93.855 - Allergy and Infectious Diseases Research, aims to study molecular mechanisms of Plasmodium parasite invasion in Anopheles mosquito midguts to identify novel targets for transmission-blocking malaria vaccines. The key products and services to be delivered under this award include: Functional characterization of identified mosquito and parasite proteins that mediate...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $512,581 to Iowa State University of Science and Technology to conduct research on the influence of prostaglandin E2 (PGE2) on insect innate immune function, with a focus on the mosquito, Anopheles gambiae. The research aims to examine the cellular and transcriptional events following PGE2 activation, the mechanisms of...
This $583,047 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to understand how Rift Valley Fever Virus (RVFV) disseminates from the site of infection in the skin to the central nervous system (CNS). The project aims to establish the routes and mechanisms by which RVFV invades the CNS following peripheral exposure, using novel rodent CNS infection models...
The University of Florida received a $135,107 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop a novel methodology using X-ray micro-computed tomography (micro-CT) imaging to accurately quantify mosquito blood-feeding rates. This 2-year project aims to optimize micro-CT protocols, develop imaging standards and diagnostic keys, and validate the reliability of this innovative...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $707,696 to The Johns Hopkins University from November 2024 through October 2029. The funding supports research to identify volatile organic compounds in human scent signatures that modulate attractiveness to the African malaria mosquito Anopheles gambiae, a key disease vector. The research aims to characterize...
This Cooperative Agreement award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $606,815.00 to Duquesne University to develop field-ready paratransgenic bacterial strains that can interfere with the ability of mosquitoes to transmit malaria parasites. The project aims to engineer Asaia bogorensis strains that are optimized for anti-Plasmodium performance, resistance to horizontal transfer,...