Project Grant R16AI177410

Award Date 9/1/24
Completion Date 8/31/28
Dollars Obligated $177K
Federal Grant Program
93.855
Assistance Type
Project Grant
Place of Performance
Bowling Green, KY, USA
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The study aims to: 1) investigate DNA methylation patterns in macrophages infected with L. pneumophila compared to uninfected controls, and 2) analyze the interactions between L. pneumophila "nucleomodulins" (effector proteins that translocate to the host cell nucleus) and histone/non-histone proteins using chromatin immunoprecipitation sequencing and co-immunoprecipitation assays. The research is expected to elucidate how bacterial nucleomodulins mediate regulatory control through epigenetic changes during intracellular infections, which can inform the development of new therapeutic approaches. The award will also expand research and educational opportunities for undergraduate students at Western Kentucky University, the primary awardee for this grant.

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