This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), will support research on manipulating the DNA damage response and proteome on viral genomes during herpes simplex virus (HSV) infection. The $651,832 award, with a project period from November 2024 to October 2029, will enable researchers at The Children's Hospital of Philadelphia to conduct a multi-modal proteomic...
This federal Project Grant award, provided under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program administered by the National Institute of Neurological Disorders and Stroke (NINDS), aims to define the pathobiological trajectory of early-onset neurological disorders in relation to methylglyoxal, microvascular leakage, and inflammation in HIV-1 infected humanized mouse models. The $652,375 award will also assess whether lowering...
This Project Grant award of $363,969 from the National Institute of Neurological Disorders and Stroke (NINDS) under CFDA 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders will support research to characterize the mechanisms by which thyroid hormone regulates HSV-1 latency and reactivation in neurons. The project aims to use computer-guided mutagenesis to generate chimeric viruses and investigate how thyroid hormone binding and neuronal excitability impact...
This Project Grant award, valued at $430,170.00 and provided by the National Institute of Allergy and Infectious Diseases (NIAID) under CFDA Program 93.855 Allergy and Infectious Diseases Research, supports research to identify genetic determinants of neurotropism in Enterovirus D68 (EV-D68). The overarching goal is to utilize a human spinal cord organoid (HSCO) model to determine viral genetic factors that enable EV-D68 to target the central nervous system and cause acute flaccid myelitis, a...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $2,503,949 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to Rockefeller University. The grant, awarded on May 1, 2025, supports a research project titled "Applying RNA Logic in Space and Time to Neurologic Disease". The project aims to develop new techniques and concepts to discover therapeutic targets for neurological diseases by studying...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855), provides $658,273 to the University of Massachusetts Medical School to study how Herpes Simplex Virus 1 (HSV-1) interacts with and regulates the NLRP1 inflammasome pathway in human skin cells. The key goals are to identify the mechanisms by which HSV-1 activates and inhibits the NLRP1 inflammasome, and to...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $682,879 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The Medical College of Wisconsin, Inc. to conduct research on the impact of human cytomegalovirus (HCMV) infection on the development of human neural tissues. The 5-year project aims to: 1) define the transcriptional and cellular disruptions to developing human neural cells caused by HCMV infection, 2) determine the...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $168,455 to New York University School of Medicine to investigate the role of region-specific reactive astrocyte factors in neuroinflammation. The key objectives are to: Assess the effect of hepatocyte growth factor (HGF) expressed by telencephalic reactive astrocytes on...
This $444,125.00 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will be used by the University of California, San Francisco (UCSF) to conduct research on the brain maturation-dependent mechanisms underlying hemorrhagic transformation after delayed reperfusion in perinatal and childhood ischemic stroke. The key objectives are to: 1)...
This federal Project Grant award, totaling $215,810.00, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant supports research to identify host proteins degraded in neurons by the Herpes Simplex Virus (HSV-1) and the roles of the viral proteins ICP0 and PUL55/PUL13/PUS10 in protein degradation and viral reactivation from latent infection. The primary awardee is the Rector &...