This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $231,826.00 to Duquesne University to conduct research on the role of microglia/macrophages in Lewy body disorders. The primary objectives are to: 1) identify the neural cell type most likely to harbor alpha-synuclein aggregates and determine if these cells can be...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, provides $414,191 to Drexel University to investigate the relationship between the molecular structure of alpha-synuclein (α-syn) protein fibrils and the emergence of distinct neurological disorders like Lewy body dementia, Parkinson's disease, and multiple system atrophy. The...
This $406,260 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program will fund research to understand the spread of alpha-synuclein aggregates, which is believed to be a key mechanism underlying the onset and progression of Parkinson's disease (PD) and related dementias. The research aims to use fluorescence lifetime imaging microscopy...
This Project Grant award, with identification number R01NS135829, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The project aims to investigate the role of N-terminal acetylation in regulating alpha-synuclein stability, function, and potential therapeutic targeting for Parkinson's disease and related neurodegenerative disorders. The...
This $231,255 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program supports research to identify the source and pathogenic properties of alpha-synuclein protein strains found in the plasma of Parkinson's disease patients. The goals are to use extracellular vesicles to uncover the tissue origin of these plasma alpha-synuclein strains...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to develop novel nanobody-based agents targeting intracellular and extracellular alpha-synuclein aggregates to block the prion-like propagation of Lewy body dementias. The $2,280,379 award to the Regents of the University of Michigan, effective September 19, 2024 through August...
The National Institute on Aging's Aging Research Federal Grant Program (CFDA 93.866) awarded a $7,704,350 Project Grant to The Trustees of the University of Pennsylvania, doing business as Clinical Practices of the University of Pennsylvania, for the research project "Mechanisms Underlying Heterogeneity of Cognitive Outcomes in Synucleinopathy". The project aims to understand why the same underlying pathology, namely inclusions of alpha-synuclein, varies widely in the pace and...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $441,500 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to Duquesne University of the Holy Spirit. The purpose of this 3-year grant, beginning September 2023, is to utilize laboratory data and computational 3-D modeling to analyze the role of the central amygdala in neuropathic pain. Specifically, the project aims to build a proof-of-concept 3-D...
This $2,192,716 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) aims to understand the role of serine-129 phosphorylation in the aggregation and spreading of α-synuclein pathology associated with Parkinson's disease, dementia with Lewy bodies, and related synucleinopathies. The project leverages novel serine-129 phospho-deficient and...
This $475,369 federal Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to better understand how microglia (the brain's resident macrophages) are programmed by the brain environment following transplantation. The primary awardee, The Trustees of the University of Pennsylvania, will use single-cell RNA and ATAC sequencing to...
This $894,922 National Institutes of Health National Institute of Neurological Disorders and Stroke project grant supports research at Duquesne University from September 2022 to August 2025 under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program.
The grant funds research to test the hypothesis that myelination is linked to resilience against limbic alpha-synucleinopathy and is modified by microglia/macrophages. Specifically, the university will leverage an in vivo model of limbic alpha-synucleinopathy to study the relationship between myelination markers and disease outcomes, and to investigate how hypomyelination/demyelination and microglia/macrophage depletion/repopulation impact pathology. Recombinant alpha-synuclein proteins and pre-formed fibrils will be generated by the University of Pennsylvania subaward ($4-8k annually) for use in the studies. The University of Pittsburgh subaward will provide guidance on experimental design and data interpretation. The research aims to advance understanding of potential links between myelination and Lewy-related pathologies while training students, and appears aligned with the goals of the supporting NIH grant program.