Project Grant R15HL170174
- This federal Project Grant award, provided by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research), will fund research to investigate place-based factors contributing to sleep health disparities in the United States. The $177,385 award to Brigham & Women's Hospital Inc., a subsidiary of Partners Healthcare System, will: 1) Estimate sleep health measures and environmental circadian misalignment across different populations and geographies; 2) Examine...
- This Project Grant award for $730,993.00 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research to investigate the mechanisms by which internal circadian misalignment contributes to the cardiometabolic risk associated with sleep loss. The project aims to determine if preventing light exposure and food intake during the circadian biological night can mitigate the adverse cardiometabolic effects of insufficient sleep. Researchers at...
- This federal Project Grant award for $743,388, awarded by the National Heart, Lung, and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837), supports research on the mechanisms by which sleep loss and circadian misalignment contribute to insulin resistance and the development of Type 2 diabetes mellitus. The award will fund two randomized controlled trials with 48 adult participants to characterize the role of cortisol rhythms and downstream metabolomic and endocrine...
- This federal Project Grant award, totaling $1,621,874.00, was provided by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837) with an award date of Sep 23, 2025 and an ultimate completion date of Jun 30, 2027. The award was granted to Brigham & Women's Hospital Inc., a subsidiary of the larger Partners Healthcare System (now Mass General Brigham), to conduct research on the role of ambient lighting in circadian misalignment and its...
- This federal Project Grant award for $696,470, provided by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research), aims to investigate the relationship between prenatal maternal sleep and cardiovascular disease risk in offspring. The University of Denver is the primary awardee, and they have sub-awards with Northwestern University and the University of Colorado, Anschutz Medical Center. The key objectives are to: 1) examine how prenatal maternal sleep...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $594,547 to Harvard Medical School to conduct research on the regulation of arousal and sleep quality. The project aims to characterize a gut-to-brain signaling pathway that uses information about ingested nutrients to control arousal levels and sleep depth, without affecting overall sleep duration. The research will investigate...
- This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $818,279 to Brigham & Women's Hospital, a subsidiary of Partners Healthcare System, to conduct research on improving the subtyping and characterization of obstructive sleep apnea (OSA). The project will leverage data from existing research cohorts and a clinical biobank to quantify the reproducibility of OSA severity markers and derive physiologically...
- This $782,473 federal Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research to improve understanding of the pathogenesis of sleep apnea using novel imaging techniques during sleep. The project aims to characterize the site and pattern of airway collapse as well as how upper airway anatomy mediates this collapse, which could provide new insights to guide optimal therapies, particularly for patients who cannot tolerate...
- This federal Project Grant award, valued at $755,257.00, was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The award aims to study the role of GPI-anchor biosynthesis in regulating sleep, with the goal of improving understanding of the genetic factors underlying sleep disorders such as insomnia. The research will be conducted by Texas A&M University and will involve a multi-pronged approach, including...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) aims to elucidate the complex relationship between obstructive sleep apnea (OSA) and cardiovascular disease (CVD). The $1,296,660 award supports a 24-month research project that will employ a "bed to bench" approach integrating clinical, computational, and in vitro techniques. Key objectives include developing and validating a mathematical model to quantify...
This federal Project Grant award, provided by the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research), supports a comprehensive sleep neuroimaging study to investigate the role of local sleep disturbance in obesity risk. The $568,125 award to Brigham Young University, with a period of performance from September 2025 to August 2028, will utilize advanced functional neuroimaging and polysomnographic methods to elucidate the underlying mechanisms linking poor sleep and obesity. The research aims to identify modifiable behavioral and physiologic targets to reduce obesogenic risk factors, leveraging the university's expertise in areas such as medical sciences, engineering, and biological research. This grant is part of the Institute's broader efforts to foster innovative cardiovascular disease research and train the next generation of scientific talent in this critical domain.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $568.1k | 9/8/25 |