Project Grant R15HD123283
- The National Institute of Child Health and Human Development awarded the University of Massachusetts Medical School $716,119 on July 25, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate dietary signaling mechanisms in male reproductive tissues and their epigenetic effects on offspring. The project explores how paternal dietary exposures influence cell composition and gene regulation in the testis, epididymis, and seminal vesicle, and...
- The National Institute of Child Health and Human Development awarded Harvard Medical School (operating through the Office of Research Administration of President and Fellows of Harvard College) $464,750 on August 24, 2026, under the Child Health and Human Development Extramural Research Program (CFDA 93.865). The award funds research on genetic variation in genes controlling sperm-egg interactions in reproductively isolated populations of the fish species Astyanax mexicanus. The research...
- The National Institute of Child Health and Human Development awarded the University of Massachusetts $157,427 on May 25, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate the role of maternal MCM4 protein in zygotic DNA replication and the oocyte-to-embryo transition. The research uses live imaging, immunofluorescence, and RNA sequencing to examine how maternal MCM4 governs zygotic replication and mitotic fidelity in oocyte-specific...
- The National Institute of Child Health and Human Development awarded the University of Massachusetts Medical School $103,686 on February 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to support research probing the mammalian PIRISC cleavage mechanism. The funded research investigates how gametocyte-specific factor (GTSF) proteins accelerate the cleavage activity of PIWI-interacting RNA-induced silencing complexes (PIRISC), which silence...
- The National Institute of Child Health and Human Development awarded University of Massachusetts Boston $515,382 on June 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to support research on cellular regulation of pattern in regenerating limb tissue. The research examines how anterior and posterior limb cells direct regeneration of precisely the missing structures in Mexican axolotl limbs, using spatial transcriptomics and in vivo regenerative...
- The National Institute of Child Health and Human Development awarded the University of Massachusetts $478,453 on September 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to characterize approximately 150 early lethal mouse phenotypes occurring between fertilization and organogenesis as part of large-scale analysis of International Mouse Phenotyping Consortium (IMPC) early lethal phenotypes. The recipient will phenotype knockout alleles to...
- The National Institute of Child Health and Human Development awarded $430,375 to the University of California Santa Cruz on August 1, 2026, under the Child Health and Human Development Extramural Research Projects program (CFDA 93.865) to investigate the role of RNA-modifying enzymes in regulating totipotent gene expression during early embryonic development. The research explores how the putative RNA methyltransferase METTL7A1 regulates zygotic genome activation and totipotency in mouse...
- The National Institute of Child Health and Human Development awarded the University of Rochester $149,190 on February 1, 2026, under the Child Health and Human Development Extramural Research Projects program (CFDA 93.865) to investigate the molecular mechanisms of sperm dysfunction induced by meiotic drive. The project combines gene editing, genetic, and cytological approaches to study segregation distorter (SD), a sperm-killing male meiotic driver found in natural populations of Drosophila...
- The National Institute of Child Health and Human Development awarded Trustees of Dartmouth College $450,250 on June 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate how three RNA-binding proteins—PATL2, PUM1, and PUM2—regulate translational control during oocyte meiosis and early embryogenesis in a mouse model. The research uses cutting-edge technologies to define the unique and shared mRNA targets of these proteins and determine...
- The National Institute of Child Health and Human Development awarded The University of Texas Southwestern Medical Center $500,118 on August 15, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to conduct research on the molecular control of endoplasmic reticulum remodeling during spermiogenesis. The research investigates how spermatids compact the endoplasmic reticulum (ER), the largest intracellular organelle, during the morphological transformation...
The National Institute of Child Health and Human Development awarded University of Massachusetts Boston $577,974 on August 24, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate RNA binding proteins in the maintenance of male fertility and spermatogenesis. The research uses zebrafish as a model organism to elucidate how RNA regulation by ADAD1 proteins controls spermatogonial stem cell maintenance and differentiation during continuous sperm production. The project's three aims test the hypothesis that ADAD1 directly regulates RNA targets: Aim 1A identifies testis RNAs directly bound by ADAD1 and determines whether these RNAs are stabilized, destabilized, or unaffected during spermatogenesis; Aim 1B employs cell-based assays to determine how RNAs are affected upon interaction with ADAD1 protein and which protein domains are critical; and Aim 1C tests conservation of human and mouse ADAD1 function. Work is performed at the University of Massachusetts Boston location in Dorchester, Massachusetts. The period of performance runs through July 31, 2029. The award is classified as a Project Grant and represents assistance funding to support extramural research training and investigation within NICHD's child health mission.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $578.0k | 8/20/26 |