Project Grant R15GM160944
- The National Institute of General Medical Sciences (NIGMS) awarded a $248,999.00 Project Grant under CFDA program 93.859, Biomedical Research and Research Training, to the University of North Carolina at Chapel Hill (UNC-CH). The grant, awarded on July 10, 2025, supports a research project titled "Regulation of Oxidative Stress Signaling by Tyrosine Phosphorylation of Antioxidant Enzymes". The project aims to gain network-level insight into the regulation of the oxidative stress...
- This federal Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program provides $250,000 to Professor Chekan and students at the University of North Carolina Greensboro (UNC-G) to study new enzyme catalysts for crosslinking amino acid side chains in peptides. The researchers will use directed evolution and engineering approaches to improve the substrate scope and catalytic properties of copper-dependent enzymes, with the goal of...
- The National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) awarded a $448,536 project grant to the University of North Carolina at Charlotte (UNC Charlotte) to investigate the luminescence properties of protein-metal nano-complexes. The research aims to elucidate the common luminophore motif in these materials, which have diverse applications in imaging, nanomedicine, and sensing. The 3-year project will combine spectroscopy...
- This $244,450 Project Grant, awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to understand the catalytic mechanisms, structural dynamics, and biomedical importance of two key classes of metalloenzymes: matrix metalloproteinases (MMPs) and iron(II)/2-oxoglutarate (2OG)-dependent oxygenases. The project, spanning July 2025 to June 2030, aims to provide missing knowledge on these...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) aims to define the binding characteristics and functional signaling potential of CXCL12 SS1-strand binding peptides in modulating CXCR4 and CXCR7 receptor activities. The $461,992 award to the University of North Carolina at Charlotte will support research to better understand how CXCL12 chemokine heterodimers regulate immune and cancer cell...
- This federal Project Grant award, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to advance the design of bifunctional chelators (BFCs) for copper-based radiopharmaceuticals. The $398,750 award to Brown University aims to overcome longstanding challenges in the development of copper-based radiopharmaceuticals by improving the in vivo kinetic stability of BFCs. The research will...
- The University of California, Los Angeles (UCLA) received a $433,125.00 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) on July 1, 2025. The grant supports UCLA's research to investigate the novel role of histone H3 as a copper reductase enzyme, which regulates copper oxidation state and impacts copper-dependent cellular activities like mitochondrial respiration. Over the 5-year...
- This Project Grant award, funded by the National Science Foundation (NSF) Division of Chemistry under the Mathematical and Physical Sciences Federal Grant Program (CFDA 47.049), supports research at the University of Texas at Austin to study how the secondary coordination sphere (SCS) affects the activity of copper enzymes. The $594,870 award from August 1, 2024 to July 31, 2027 employs a novel biosynthetic approach to modulate copper enzyme activity, with potential applications in areas like...
- This Project Grant award, valued at $1,843,775.00 and provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to identify and characterize DNA-protein cross-links (DPCs) and their associated repair pathways. The principal investigator at the University of Kansas Center for Research Inc. will use advanced mass spectrometry techniques to profile the molecular signatures of DPCs across...
- This Project Grant award, valued at $379,394.00, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award supports a research project investigating the mechanisms by which human cells detect and respond to oxidative stress, with a focus on understanding the dose-dependent activation of key stress response proteins. The research aims to uncover how dynamic stress response pathways influence cell...
This $577,500 Project Grant, awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), will fund research at the University of North Carolina at Charlotte to investigate the regulation of the copper chaperone protein CCS. The project aims to (1) explore how phosphorylation of CCS impacts its copper-binding and transfer properties, (2) characterize the cellular effects of this modification, and (3) identify the kinases and phosphatases responsible for adding and removing this phosphorylation. This multidisciplinary study employs protein chemistry, biochemical assays, and cellular models to provide insights into the regulation of copper homeostasis, which is critical for processes like respiration, antioxidant defense, and protein quality control. The findings may open new avenues for therapeutic interventions targeting diseases associated with copper imbalance, such as ALS and cancer. The project will also provide training opportunities for junior researchers, including undergraduate students.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $577.5k | 8/21/25 |