The University of Connecticut Health Center (UCHC) has been awarded a $416,250 Project Grant by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The purpose of this 5-year grant is to support UCHC's research on the molecular mechanisms governing the mitochondrial stress response in human cells. Specifically, the research aims to elucidate how cells integrate various mitochondrial stress response pathways, including the Integrated Stress Response (ISR) involving the OMA1-DELE1-HRI signaling cascade, to maintain mitochondrial homeostasis. This work is expected to advance the understanding of mitochondrial dysfunction in diseases such as primary mitochondrial disorders and neurodegenerative conditions, potentially identifying new therapeutic targets. The grant provides funding for UCHC's utilization of reporter-based assays, CRISPR screens, in vitro reconstitution studies, and proteomics approaches to comprehensively investigate the molecular mechanisms of mitochondrial stress sensing, signaling, and response.
Generated 2/25/25, 4:14 AM