This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under CFDA 93.859 Biomedical Research and Research Training program, aims to establish an integrated bioengineering framework to better understand how the combination of soluble and bound factors governs cell signaling and modulates cell function, with a focus on chronic wound angiogenesis and healing. The $1,110,052 award, spanning from July 1, 2024 to May 31, 2029, will leverage advanced biomaterials...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS Biomedical Research and Research Training Program, CFDA 93.859) in the amount of $400,825 supports research to understand the complex cell population dynamics that result in successful wound healing versus pathological healing outcomes. The University of Illinois, the awardee, will use state-of-the-art single cell and spatial sequencing technologies to systematically compare cell type dynamics, cell-cell...
This Project Grant award from the National Institute of General Medical Sciences (CFDA 93.859 Biomedical Research and Research Training) is providing $1,139,265 to Purdue University from July 1, 2024 to April 30, 2029 to develop advanced in vitro models using tunable hydrogel platforms. The goal is to gain fundamental understanding of how endogenous cells interact with the complex biophysical and biochemical properties of the provisional wound matrix and implanted hydrogels. This will support...
This $400,000 Project Grant award, issued by the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 Biomedical Research and Research Training program, supports research to develop and optimize bioengineered polymers with tunable properties to modulate inflammatory responses in the wound microenvironment. The goal is to enhance tissue repair and regeneration across different wound types, particularly for chronic wounds. The project will investigate how biopolymer surface...
This $1,617,565 federal Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) supports research and development of a modular hybrid biomaterial delivery platform for short interfering RNA (siRNA) therapeutics. The overall objective is to construct a versatile, multi-functional lipoproteoplex (LPP) nanovehicle that can effectively...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $349,345 to Fesariustherapeutics Inc. to develop and demonstrate the feasibility of an advanced dermal regeneration scaffold called Dermisphere for the management of acute major burn wounds. Dermisphere aims to regenerate dermis in full-thickness skin loss wounds significantly faster than current market-leading dermal replacement...
This $543,826 Project Grant was awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research at the University of Pittsburgh to develop novel bioengineered regenerative medicine solutions for promoting vascular tissue regeneration and wound healing. The key objectives are to: 1) Test the significance of vasculogenic fibroblasts in tissue repair...
This is a federal Project Grant award of $389,211 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859). The award will fund research to study the fundamental mechanisms of gap closure during wound healing and tissue homeostasis, with a focus on understanding how tissue fluidity and cell migration patterns regulate this process. The research will involve tracking cell kinematics, force distribution, and tissue...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded Lynntech Inc. a $687,416 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to develop a cutaneous gel that can controllably deliver a small molecule therapeutic to effectively treat diabetic foot ulcers (DFUs). The project aims to (1) prepare and characterize a preferred gel formulation for controlled delivery, (2) further elucidate the therapeutic's...
This Project Grant award, valued at $607,398.00, was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The funding supports research by Albany Medical College to investigate the role of the epidermal integrin α3β1 in age-related changes during cutaneous wound healing. The research aims to determine how the waning function of this integrin in aging skin contributes to...