This federal Project Grant award for $1,617,565.00, provided by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the "Discovery and Applied Research for Technological Innovations to Improve Human Health" (CFDA 93.286) program, supports the development of a "Modular Toolbox of Protein and Lipid Hybrid Biomaterials for siRNA Delivery". The project aims to construct a versatile, multi-functional platform technology, termed "Lipoproteoplex (LPP)", for the effective delivery of short interfering RNA (siRNA) sequences to treat chronic diabetic skin wounds. The research focuses on engineering cationic supercharged proteins and optimizing their interactions with lipid shells to enhance the overall efficacy of the LPP delivery system. The expected outcome is an adaptable LPP formulation that can overcome the endosomal escape barrier and achieve efficient cytosolic siRNA delivery, with the long-term goal of translating this technology to a wide array of monogenic cutaneous disorders. The project period runs from August 1, 2024 to May 31, 2028.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $527.2k | 5/14/25 | ||
| Not listed | $545.2k | 7/19/24 | ||
| Not listed | $545.2k | 7/19/24 |