Project Grant R15DK140841
- This $172,232 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research to understand the causes of inflammatory bowel disease (IBD) therapy failure. The principal investigator, Dr. Simon M. Gray, a gastroenterologist at the University of North Carolina at Chapel Hill, will leverage a pre-clinical mouse model to study the immunologic and...
- This $647,290 federal Project Grant was awarded on July 1, 2025 by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research conducted by the University of California, Los Angeles (UCLA) to study the interplay between brain oxytocin and CRF (corticotropin-releasing factor) systems in stress-related visceral analgesia versus hyperalgesia, and the...
- This Project Grant award of $2,095,736.00, funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports a research project investigating the response of the commensal gut microbiota to host physiological stress. The award, provided to the University of Arizona, aims to utilize a novel non-model rodent system, free-living North American red squirrels, to identify the molecular mechanisms underlying...
- This Project Grant award of $234,000 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research at the University of Colorado-Denver to investigate the role of the Aiolos transcriptional regulator in the pathogenesis of inflammatory bowel disease. The researchers aim to utilize CRISPR-Cas9 genome editing to examine how Aiolos regulates T cell...
- This federal Project Grant award of $151,643 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research by Dr. Ornelas Sanchez at the University of Colorado-Denver to investigate the use of proteolysis targeting chimeras (PROTACs) to regulate hypoxia-inducible factors (HIFs) and their potential therapeutic applications for inflammatory bowel disease (IBD)....
- This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $549,140 to the University of Miami to investigate the role of the bacterial signaling molecule autoinducer-2 (AI-2) in mediating the mammalian stress response and its impact on stress-related behaviors and neurobiological factors. The 5-year project aims to: 1) determine if stress regulates gut bacterial production of AI-2, 2) assess how bacterial...
- This federal Project Grant award of $147,486 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) will fund research to investigate the role of gut microbes in regulating interleukin-22 (IL-22) levels in the pancreas and the impact on pancreatic health and disease. The research aims to determine how gut microbe-induced IL-22 affects pancreatic gene expression and the underlying cellular mechanisms, as well as the beneficial and detrimental effects of this...
- This $168,296 Project Grant was awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), to Weill Medical College of Cornell University. The grant supports a 5-year research career development program focused on investigating the role of a key enzyme in group 3 innate lymphoid cells (ILC3s) that regulates gut physiology. The central hypothesis is that ILC3s possess...
- This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $734,612.00 to conduct research on the mechanisms through which stress and obesity reprogram monocyte and macrophage populations in response to elevated glucocorticoid levels. The research aims to elucidate how glucocorticoids induced by early-life stress and diet-induced...
- This federal Project Grant award of $117,000 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) will support research on the role of substance P and its receptor MRGPRX2 in the pathophysiology of irritable bowel syndrome (IBS). The Regents of the University of Michigan, through its Office of Research and Sponsored Projects, will conduct the research project from June 2025 to May 2027. The...
This Project Grant award of $554,874 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research program) supports research at Northern Illinois University to investigate the role of the gut-brain-microbiota axis in the development of inflammatory bowel disease (IBD) induced by long-term stress. The key objectives are to determine how prolonged social isolation and IBD induction affect the gut microbiome of prairie voles, with the goal of elucidating the interplay between chronic stress, altered behaviors, and changes in the gut microbiome that can lead to IBD. Preliminary findings indicate differences in microbial markers associated with stress and colitis. This 3-year research project, running from August 2025 to July 2028, aims to provide insights into potential interventions for individuals with IBD or facing physiological stress by unraveling these complex interactions.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $554.9k | 8/14/25 |