Project Grant R13HD110212

MICRONUTRIOMICS FOR POPULATION-LEVEL WOMEN, INFANT, AND CHILD-FOCUSED PUBLIC HEALTH INTERVENTIONS - 1 PROJECT SUMMARY/ABSTRACT 2 3 OMIC METHODOLOGIES CAN IMPROVE OUR UNDERSTANDING OF THE METABOLIC, PROTEOMIC AND GENOMIC 4 CONSEQUENCES OF MICRONUTRIENT DEFICIENCIES AND INTERVENTIONS IN UNDERNOURISHED POPULATIONS INCLUDING 5 PREGNANT WOMEN, CHILDREN AND ADOLESCENTS. SPECIFICALLY, THIS CONFERENCE WILL EXAMINE THE USE OF NEW 6 OMIC TECHNOLOGIES AND METHODS TO ASSESS THE EFFECTS OF NUTRITIONAL STATUS ON HEALTH; IMPROVE 7 ASSESSMENT AND INTERVENTIONS; AND BROADEN KNOWLEDGE ON THE IMPACT OF NUTRITION ON PREGNANCY AND 8 FETAL, CHILD AND ADOLESCENT GROWTH AND DEVELOPMENT. THE USE OF OMICS TO DETECT THE IMPACT OF 9 MICRONUTRIENT INTERVENTIONS WILL RESULT IN TREMENDOUS PUBLIC HEALTH LEARNINGS RELATED TO PREGNANCY 10 OUTCOME AND CHILD DEVELOPMENT. 11 12 LOW INTAKES OF MANY MICRONUTRIENTS ARE COMMON IN MANY UNDERREPRESENTED POPULATIONS, RESULTING IN 13 CHRONIC, MARGINAL DEFICIENCIES WHICH MAY NOT PRODUCE CLINICAL SYMPTOMS, BUT LIKELY CAUSE UNDERLYING 14 METABOLIC CHANGES THAT ARE DIFFICULT TO IDENTIFY. SIMILARLY, MICRONUTRIENT INTERVENTIONS, EITHER WITH SINGLE 15 OR MULTIPLE MICRONUTRIENTS, ARE LIKELY TO CAUSE MYRIAD METABOLIC CHANGES OF CONSEQUENCE TO HEALTH THAT 16 ARE NOT YET IDENTIFIED. OMICS IS A POWERFUL TOOL THAT WILL ELUCIDATE THE EFFECTS OF MICRONUTRIENT 17 DEFICIENCIES AND INTERVENTIONS AT THE POPULATION LEVEL. LITTLE IS KNOWN ABOUT SUBCLINICAL AND/OR MARGINAL 18 MICRONUTRIENT DEFICIENCIES ON METABOLISM AND HEALTH OF UNDERREPRESENTED POPULATIONS, OR THE EFFECTS OF 19 MICRONUTRIENT INTERVENTIONS ON THE METABOLOME, THE GENOME OR THE PROTEOME. GIVEN THE ENORMOUS 20 ONGOING EFFORTS IN MICRONUTRIENT SUPPLEMENTATION AND FORTIFICATION WORLD-WIDE, THESE ARE CRITICAL 21 KNOWLEDGE GAPS. CONVENING EXPERTS IN OMICS AND EXPERTS IN POPULATION-LEVEL MICRONUTRIENT NUTRITION 22 RESEARCH AND INTERVENTION PROGRAMS AND THE PLANNED COLLABORATIVE DISCUSSIONS WILL HIGHLIGHT FUTURE 23 JOINT RESEARCH OPPORTUNITIES, AS WELL AS AVAILABLE SAMPLES AND ANALYSES, FOR BOTH BASIC AND APPLIED 24 INVESTIGATORS IN THE AREA OF PUBLIC HEALTH NUTRITION SPECIFIC TO MATERNAL AND CHILD HEALTH. THE CONFERENCE 25 WILL ALLOW RESEARCHERS TO PRIORITIZE EXISTING SAMPLES AND ANALYSES OF MATERNAL AND BIRTH TO 24-MONTHS 26 POPULATIONS THAT ARE AVAILABLE AND IDENTIFY INVESTIGATORS WHO WILL LEAD FUTURE OMICS ANALYSES. THROUGH 27 OMICS, WE CAN UNDERSTAND AND IMPROVE OUTCOMES OF GLOBAL PUBLIC HEALTH IMPORTANCE RELATED TO HIGH- 28 RISK PREGNANCY, CHILD AND ADOLESCENT GROWTH, WASTING, STUNTING, INFLAMMATION, MATERNAL AND CHILD 29 SURVIVAL, AND DISEASE PREVENTION.