Project Grant R00HD112600
- The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) awarded a $446,875 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to the Trustees of the University of Pennsylvania, doing business as the Clinical Practices of the University of Pennsylvania. The grant, awarded on August 15, 2025 with an ultimate completion date of July 31, 2027, will fund the development and evaluation of a "Disparities in Labor...
- This $178,000 Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) supports research to develop an early life phenotyping framework for very preterm infants. The research aims to create 'perinatal phenotypes' by integrating variables such as reason for preterm birth, intrapartum care, and neonatal presentation, and then determine how these phenotypes contribute to...
- This Project Grant award of $249,000 was provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) to the University of Connecticut Health Center (UCHC). The funding will support a 3-year research project to study the transcriptional regulation and intercellular signaling at the maternal-fetal interface, with the goal of developing a prognostic model to relate individual...
- This $163,145 Project Grant awarded on August 7, 2025 by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research Program (CFDA 93.865), aims to address critical questions pertaining to impaired placentation associated with fetal growth restriction (FGR). The principal investigator, a pediatric and fetal surgeon, will use this 5-year award to develop unique cross-disciplinary skills and...
- This Project Grant award, totaling $601,499 and spanning from June 2025 to May 2030, was provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant supports research focused on understanding how maternal obesity during pregnancy alters mitochondrial function in the offspring, which is linked to the later development of obesity and metabolic syndrome. Key objectives include:...
- This Project Grant award of $167,353 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research Federal Grant Program (CFDA 93.865), supports research on the placental histopathology and transcriptomic changes associated with syphilis in pregnancy. The central objective is to elucidate T. pallidum-driven alterations in the maternal-placental-fetal immune transcriptome, and link these changes...
- The U.S. National Institute of Child Health and Human Development (NICHD) awarded a $766,982 Project Grant to Carnegie Mellon University under the Child Health and Human Development Extramural Research program (CFDA 93.865). The project aims to develop and validate a novel computational framework to simulate uteroplacental hemodynamics and placentation, with the goal of identifying metrics for early detection of pregnancy complications related to abnormal placental formation. This research...
- The National Institute of Child Health and Human Development (NICHD) has awarded a $423,985 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to the University of Illinois to develop a novel non-invasive monitoring system for detecting placental dysfunction and associated pregnancy complications. The funding will support research to utilize extracellular vesicles (EVs) circulating in maternal blood as biomarkers, using a "target recycling...
- This Project Grant award of $765,571 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research on placental fatty acid metabolism in gestational diabetes mellitus (GDM). The project aims to investigate sexual dimorphism in placental function and its role in adverse pregnancy outcomes associated with GDM, with a focus on understanding the effects of GDM...
- This $429,000 federal Project Grant award, funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research to investigate the gene and environmental influences on placental angiogenesis and severe fetal growth restriction. The University of Colorado-Denver, the awardee organization, will leverage induced pluripotent stem cell technology to better...
This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $249,000.00 to The Trustees of the University of Pennsylvania, doing business as Clinical Practices of the University of Pennsylvania, to enhance personalized insights into common obstetric disorders using longitudinal deep-phenotyping data. The project aims to compile a comprehensive pregnancy dataset that evaluates women's health throughout pregnancy, including longitudinal blood/urine multiomics data paired with clinical, survey, behavioral, and environmental data from 200 participants (100 with adverse outcomes). Using a data-driven systems biology approach, the research will define normal placental and pregnancy systems biology and investigate disease mechanisms in common obstetric disorders such as preterm birth, fetal growth restriction, and preeclampsia. Key objectives include evaluating molecular network differences in obstetric disorders, determining network structures and transcription factors associated with specific disorders, and identifying molecular network disruptions linked to these conditions.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $249.0k | 9/2/25 |