Project Grant R03TR005349
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded Icahn School of Medicine at Mount Sinai a Project Grant of $730,268 on August 15, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop a versatile paired prime editing toolkit for correcting Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene mutations. The grant supports a research initiative extending through May 31, 2030, focused on creating a...
- Federal Grant Award Summary Cincinnati Children's Hospital Medical Center received a $441,375 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded August 15, 2025, with completion targeted for July 31, 2027. The award funds research to develop and optimize a dual adeno-associated virus (AAV) gene delivery system employing intein technology to deliver full-length, functional cystic fibrosis transmembrane...
- Federal Grant Award Summary Cincinnati Children's Hospital Medical Center received a $727,575 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective August 15, 2025, with completion targeted for May 31, 2030. The project will investigate the cellular mechanisms and clinical impact of the genetic variant rs7512462 within the SLC26A9 gene on individual patient responses to cystic fibrosis (CF)...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded Icahn School of Medicine at Mount Sinai a Project Grant totaling $1,175,924 under the Cardiovascular Diseases Research program (CFDA 93.837), effective April 1, 2026 through January 31, 2033. This research initiative, titled "Hemogenic Mesoderm Heterogeneity, Regulation, and Function," focuses on understanding the molecular and transcriptional mechanisms underlying embryonic hematopoietic...
- Federal Project Grant Award Summary The National Center for Advancing Translational Sciences (NCATS), under CFDA 93.350, awarded a $462,000 Project Grant to the Icahn School of Medicine at Mount Sinai (ISMMS) effective May 1, 2026, with an ultimate completion date of April 30, 2028. This award supports preclinical research investigating revumenib as a targeted epigenetic therapy for pulmonary arterial hypertension (PAH), a rare and progressive cardiopulmonary disorder. The research focuses on...
- Federal Project Grant Award Summary Icahn School of Medicine at Mount Sinai received a $2.58 million Project Grant from the National Human Genome Research Institute (NHGRI) under the Human Genome Research program (CFDA 93.172), awarded April 13, 2026, with a completion date of March 31, 2030. The award funds the development of ONTRAC (Omics Niche TRjectory Analysis Framework), a computational modeling framework designed to systematically characterize tissue microenvironment organization using...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Icahn School of Medicine at Mount Sinai a Project Grant totaling $462,000 under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop and optimize FAB-fragment drug conjugates (FDCs) as targeted immunosuppressive delivery systems for organ transplant applications. The project, which commenced February 4, 2026 and concludes January 31, 2028, will design and characterize an...
- Federal Grant Award Summary The University of California, San Francisco (UCSF) received a $731,287 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective July 1, 2026, through March 31, 2030. This award funds research investigating airway epithelial cell reprogramming mechanisms that drive chronic lung allograft dysfunction (CLAD), a condition that limits survival following lung transplantation. The...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded The Regents of the University of California, San Francisco a Project Grant of $182,060 under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate the role of the senescence marker protein P16INK4A in alveolar epithelial stem cell differentiation during lung injury and repair. The research, conducted at UCSF in San Francisco, California, commenced September 30, 2025, with completion...
- Federal Project Grant Award Summary Icahn School of Medicine at Mount Sinai received a $1,257,163 Project Grant from the National Institutes of Health Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) effective July 1, 2025, with a completion date of June 30, 2030. The award funds research into a humanized monoclonal follicle-stimulating hormone (FSH) antibody therapeutic targeting Alzheimer's disease and co-occurring health conditions in individuals with Down...
The National Center for Advancing Translational Sciences (NCATS), under CFDA 93.350, awarded Icahn School of Medicine at Mount Sinai a $168,000 Project Grant commencing May 1, 2026, and concluding April 30, 2028. This research initiative focuses on developing and characterizing a three-dimensional lung organoid model to investigate early cystic fibrosis (CF) lung disease pathogenesis and the role of cystic fibrosis transmembrane conductance regulator (CFTR) protein in fetal lung development. The research leverages both in vitro and in vivo organoid systems that recapitulate early fetal lung development through branching morphogenesis and alveologenesis to overcome the scarcity of available human fetal lung material for pediatric disease research. The project deliverables include comprehensive molecular characterization of CFTR gene transcript expression, CFTR protein expression and function, and detailed transcriptomic and proteomic profiles comparing normal and CF lung organoids. Additionally, the research will characterize cellular multi-omes in fetal normal and CF lungs to validate the lung organoid model findings. By elucidating the mechanisms through which CFTR protein deficiency contributes to pro-inflammatory states in respiratory epithelial cell populations, this research aims to inform the potential for early childhood or in utero CFTR modulator therapies to delay or prevent CF lung disease development in pediatric patients.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $168.0k | 5/5/26 |