Project Grant R03TR004613

Award Date 9/6/23
Completion Date 8/31/25
Dollars Obligated $141K
Federal Grant Program
93.350
Assistance Type
Project Grant
Place of Performance
Evanston, IL 60208, USA
Similar Awards
This federal Project Grant award, valued at $294,000 and spanning September 2024 to September 2026, was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research (CFDA 93.121) program. The grant supports research to understand the mechanisms of craniofacial cartilage differentiation from human neural crest stem cells, with the goal of developing tissue engineering approaches to repair birth defects and injuries to the head and...
This $476,886 federal Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) supports research at Boston University to develop computational models for predicting the spatiotemporal distribution of growth factors in tissue engineering scaffolds. The goal is to optimize scaffold designs to achieve optimal growth factor exposure profiles that improve tissue regeneration outcomes, particularly for cartilage repair. The research utilizes reaction-diffusion...
This $672,394.58 project grant from the National Institutes of Health's National Institute of Dental and Craniofacial Research Oral Diseases and Disorders Research program (CFDA 93.121) supports the development of a crosslinkable tissue particle implant for regenerating craniofacial bone. Led by Leefa Biotech LLC, the one-year award aims to demonstrate improved bone regeneration in critical-size cranial bone defects using the implant compared to the current standard of care. If successful, the...
This federal Project Grant award, valued at $626,879.00, was awarded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The research aims to explore a novel mouse model of large-scale bone regeneration to unravel the cellular and molecular mechanisms governing the initiation and coordination of bone repair following extensive injuries. Specifically, the research will...
This federal Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), aims to develop a novel biomaterial delivery platform to sequentially release bone morphogenetic proteins (BMP2 and BMP9) for spatiotemporal control of bone and joint regeneration in a mouse digit amputation model. The $271,664 award will fund the engineering of magnetic...
This Project Grant from the National Science Foundation Division of Materials Research provides $418,382 to Rensselaer Polytechnic Institute for research under the Mathematical and Physical Sciences program (CFDA 47.049). The award will fund development of novel implantable biomaterials composed of polymerized prodrugs of 17?-estradiol formulated as oriented electrospun microfibers embedded in an injectable hydrogel matrix. These materials are designed to slowly degrade via hydrolysis...
This $400,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to develop and optimize bioengineered polymers with tunable properties to modulate inflammatory responses in the tissue microenvironment and enhance tissue repair and regeneration across a spectrum of wound types. The overarching goal is to understand how biopolymer chemical and mechanical properties influence...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to leverage microsurgery and bioprinting techniques to engineer rapidly vascularized tissue grafts for craniomaxillofacial reconstructive surgery. The $685,594 award, spanning from June 2025 to May 2030, supports the development and evaluation of a novel microsurgical "vascular micropuncture" technique to expedite...
This Project Grant awarded by the National Science Foundation (NSF) under the Engineering program (CFDA 47.041) supports research to understand how human bone tissue dynamically adapts at the nanoscale level under various loading conditions. The $719,538 award to the Trustees of the University of Pennsylvania, made on May 1, 2024, will investigate the real-time rearrangement and deformation of the nanoscale components of healthy and osteoporotic bone tissue when subjected to cyclic loading....
This National Institute of Dental and Craniofacial Research (NIDCR) Project Grant award under the Oral Diseases and Disorders Research program (CFDA 93.121) provides $320,053 to the University of Southern California (USC) to conduct comprehensive research on the craniofacial skeleton and connective tissue development. The 8-year project will utilize advanced techniques in spatial transcriptomics and mouse genetics to identify genes and pathways regulating the assembly of the craniofacial...

The federal Project Grant award R03TR004613, funded by the National Center for Advancing Translational Sciences (NCATS - CFDA 93.350), aims to develop novel multiscale bone scaffolds using inorganic polymer materials for bone tissue regenerative engineering. The $141,478 award to North Carolina State University will fund research to optimize the synthesis of biocompatible inorganic polymer-based scaffolds, explore the mechanisms of cell attachment and migration, and investigate the ability of these scaffolds to accelerate the healing of complex craniofacial defects in animal models. This work seeks to address the limitations of existing synthetic bone grafts and orthopaedic implants by creating materials that better mimic the microstructure and mechanical properties of natural bone. The project period runs from Sep 6, 2023 to Aug 31, 2025.

Generated 8/13/24, 7:53 AM