This Project Grant award of $2,351,580.00 from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research by The Ohio State University to investigate the KCHIP2-JNK2 axis as a potential therapeutic target for sudden cardiac death (SCD) in heart failure (HF) patients. The key goals of the research are to: 1) Determine how the potassium channel interacting protein KCHIP2 regulates the expression of the JNK2 kinase, and 2) Explore how the...
The National Heart, Lung, and Blood Institute (NHLBI) awarded a $741,112 Project Grant (CFDA 93.837 - Cardiovascular Diseases Research) to The Ohio State University to conduct research on the impact of the adaptive immune system on cardiac electrophysiology. The 4-year project aims to delineate the pathophysiological role of ischemic heart failure (IHF)-activated CD4+ T-cells on cardiac dysfunction, determine electrophysiological changes in cardiomyocytes resulting from IHF T-cells, and...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to understand the function of the small conductance calcium-activated potassium (SK2) channel in astrocytes and its interaction with adrenergic signaling. The total funding amount is $433,125.00, with a project period from June 23, 2025 to May 31, 2027. The...
This Project Grant award of $157,500 from the National Center for Advancing Translational Sciences (NCATS), under CFDA 93.350, focuses on characterizing the physiological role and biophysical properties of the chloride intracellular channel 2 (CLIC2) protein. The award to The Ohio State University aims to: Establish the impact of a truncation mutation in CLIC2 on the differentiation and function of human induced pluripotent stem cell-derived cardiomyocytes. Investigate the role of CLIC2 in...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under CFDA 93.837 - Cardiovascular Diseases Research provides $570,537 to the University of California, Davis to investigate the role of calcium dysregulation in human atrial fibroblast behavior and its contribution to atrial fibrosis associated with atrial fibrillation (AF). The research aims to establish a mechanistic understanding of how calcium homeostasis in human atrial fibroblasts drives their...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $124,411.00 to the University of California, Davis to investigate state-specific drug binding to cardiac ion channels and reveal mechanisms of arrhythmogenesis. The research aims to elucidate the discrepancy in proarrhythmic risk between different drugs that block the HERG potassium channel, a major drug anti-target. Key objectives...
The federal Project Grant award of $620,371, provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), will fund research to determine the voltage-sensing domain (VSD) dynamics of cardiac ion channels from the CNBD family, which play a pivotal role in regulating the electrical properties of the heart. The overarching objective is to leverage advanced biophysical techniques, including patch-clamp fluorometry, transition...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $668,783 to the University of North Carolina at Chapel Hill to investigate the role of extracellular ion dynamics in regulating cardiac pacemaking. The research aims to define potassium ion concentration as a critical factor underlying entrained automaticity within the sinoatrial node, the heart's natural pacemaker, and identify the...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) is providing $427,625.00 to the University of Maryland, Baltimore to investigate the conformational dynamics and regulatory mechanisms of the KCNH family of potassium ion channels. The key objectives are to: Examine the voltage sensor domain and S4 helix of KCNH channels using non-canonical amino acid technology to measure structural changes...
The federal Project Grant award of $498,153.00 from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), supports research to investigate the role of the sodium/potassium ATPase (NKA) or "sodium pump" in platelet function and thrombosis. The research aims to clarify how the NKA α1 subunit regulates G protein-coupled receptors in platelets, and assess whether the NKA α1 subunit is a factor in the heightened thrombosis...