This $2,279,811 Project Grant, awarded by the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310), aims to transform the functional characterization of the gut microbiome. The grant supports the development of novel activity-based probes (ABPs) to directly measure enzymatic function and microbial mechanisms within the complex gut microbiome. The research will utilize both gnotobiotic mouse models and longitudinal cohorts of...
This Project Grant award, valued at $133,246, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The funding will support the development of flexible Bayesian statistical methods to gain a comprehensive understanding of microbial community dynamics using high-throughput sequencing data. The key objectives are to create a general method for inferring microbial community dynamics that vary with...
The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $548,949 Project Grant (CFDA 93.286: Discovery and Applied Research for Technological Innovations to Improve Human Health) to the University of California, San Diego (UCSD) to develop a novel diagnostic technique for accurately profiling the gut microbiome. The project aims to create a "living biosensor" that can record extracellular DNA as it traverses the intestinal tract, preserving information about...
This $976,771 Cooperative Agreement awarded by the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (CFDA 47.084) program will support Biomesense Inc., a for-profit biotechnology company, in the development of a novel measurement platform to enable large-scale, longitudinal studies of the gut microbiome. The key products to be delivered through this project include: (1) refinement of processes for capturing and storing microbial RNA from gut samples, (2)...
This $1,132,500 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will support research by the Engevik Lab at the Medical University of South Carolina (MUSC) to investigate the complex interactions between gut microbiota and intestinal mucus. The overarching goal is to unravel the mechanisms by which commensal gut bacteria respond to and stimulate mucus production, which plays a vital role in...
This federal Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) in the amount of $300,000 supports research by Duke University to develop an integrated experimental and computational approach to uncover the design principles governing microbiome function. The key objectives are to apply advanced machine learning techniques, high-throughput microbial community construction, and metabolomics to elucidate the molecular networks and cellular...
This $1,113,999.00 Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training Program (CFDA 93.859), aims to elucidate the structure and functions of microbially-derived metallophores and their roles in modulating microbe-microbe and community interactions within human microbiomes. The award will fund research at the University of Denver to: 1) identify metallophores produced by the human microbiota and characterize...
This Project Grant award under the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $854,736 to Weill Medical College of Cornell University to develop advanced statistical methods for analyzing longitudinal microbiome studies. The key products and services to be delivered include: Approaches for addressing batch effects in large-scale longitudinal microbiome data Improved statistical models for identifying...
This $422,931 Project Grant was awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award will fund research to characterize how specialized metabolites mediate interactions within the human microbiome, with the goal of understanding how these metabolite-driven community dynamics influence susceptibility to antimicrobial therapies. The research will integrate cheminformatics analysis of...
This National Science Foundation (NSF) Biological Sciences (CFDA 47.074) Project Grant award of $270,000 provides funding for a postdoctoral research fellowship to study the small intestinal microbiome. The key objectives are to elucidate how individual gut microbes and microbial communities respond to host factors like oxygen levels and bile acids, and how this impacts their ability to protect against pathogens. The research will leverage a novel capsule device to sample chemicals and viable...