Project Grant R03NS151269
- The National Institute of Neurological Disorders and Stroke awarded The Regents of the University of California, San Francisco $164,000 on July 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279). The award funds research into the role of T cell receptor alpha (TRAC) signaling in regulatory T cells' pain-suppressive function. The project investigates how TRAC-mediated signaling regulates neuropathic pain and aims to identify new therapeutic targets and biomarkers for...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded $150,342 to the University of Washington on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds investigation of how long-term, closed-loop, epidural spinal cord stimulation affects neuropathic pain symptoms in rats with cervical spinal cord injury. The...
- The National Institute on Drug Abuse awarded the University of Washington $100,228 on November 10, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to characterize the role of endogenous nociceptin opioid release from the central amygdala in reward outcome encoding. The recipient will conduct research examining how nociceptin-containing neurons in the central amygdala engage distinct reward properties—including reward probability and size—and project to the lateral...
- The National Institute of Neurological Disorders and Stroke awarded The Washington University $427,625 under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) on September 1, 2026, for research on imaging fibrosis formation in peripheral nerve injury. The award funds a two-year proof-of-principle study addressing fibrosis complications in surgical repair of severe peripheral nerve injuries. Research Aim 1 focuses on real-time visualization...
- The National Institute of Neurological Disorders and Stroke awarded Duke University $3,503,160 on September 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate glial-neuronal crosstalk in neuropathic pain and diabetes. The research examines how mitochondrial transfer from satellite glial cells to sensory neurons protects against neuropathic pain and how dysfunction of this process contributes to diabetic peripheral neuropathy. The project employs two specific...
- The National Institute of General Medical Sciences, part of the National Institutes of Health at the Department of Health and Human Services, awarded $236,652 to the University of Washington on August 21, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to fund research on how chronic pain modulates emergence from general anesthesia. The research will characterize how pain state alters neural activity and behavioral responses during anesthetic emergence using a...
- The National Institute of Neurological Disorders and Stroke (part of the Department of Health and Human Services National Institutes of Health) awarded Oregon Health & Science University $5.363 million on August 18, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to optimize spinal cord stimulation parameters for pain and itch management. The research investigates how epidural spinal cord stimulation engages dorsal horn circuits, specifically targeting neuropeptide Y...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke awarded a $4.04 million Project Grant to the University of Texas at Dallas for a three-year initiative (September 1, 2025 through August 31, 2028) to identify and validate therapeutic targets for chronic pain treatment. The project leverages a CRISPR-based functional genomic screening platform developed by collaborating researchers at the University of Sydney and an extensive human dorsal root ganglion...
- This federal Project Grant award, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Drug Use and Addiction Research Programs (CFDA 93.279), is focused on developing novel methods for selectively stimulating nociceptors (pain receptors) and measuring the brain's nociceptive-specific response in both healthy individuals and those with the chronic pain condition fibromyalgia. The $2,314,276 award to Emory University will fund the creation of a new...
- This federal Project Grant award for $1,587,553.00 was provided by the National Institute of Neurological Disorders and Stroke under the Drug Use and Addiction Research Programs (CFDA 93.279). The grant is focused on developing novel 5-HT3 receptor antagonists for the treatment of neuropathic pain. The key objectives are to: 1) use computational drug design approaches to identify novel 5-HT3 receptor antagonist chemotypes with potential for central nervous system (CNS) penetration and...
The National Institute of Neurological Disorders and Stroke awarded the University of Washington $176,500 on August 15, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to support research deciphering the T cell receptor repertoire of painful human neuroma. The research aims to elucidate the role of T cells enriched within neuroma tissue from patients with chronic pain resulting from traumatic nerve injury. The recipient will profile the transcriptome and T cell receptor repertoire of T cells isolated from neuroma to gain insights into antigen specificity and ligand production within the neuroma tissue. The work will test whether neuroma T cells are reactive to self-antigens such as myelin through in vitro T cell proliferation assays and immunostaining of the T cell receptor within the neuroma to determine localization in proximity to myelinating Schwann cells. Identification of expanded T cell receptors and gene usage, and understanding their reactivity toward self-peptides like myelin, is intended to set the stage for developing T cell-based therapies through local manipulation of T cell function within the nerve. The University of Washington's Office of Sponsored Programs administers the award. Performance occurs in Seattle, Washington, with an ultimate completion date of June 30, 2027. The project aligns with the NIH HEAL Initiative's mission to accelerate discovery of novel pain targets.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $176.5k | 8/14/26 |