Project Grant R01NS139141

Award Date 8/22/24
Completion Date 7/31/29
Dollars Obligated $827K
Federal Grant Program
93.853
Assistance Type
Project Grant
Place of Performance
New York, NY 10065, USA
Similar Awards
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $1,138,538 to Mayo Clinic Jacksonville (A Nonprofit Corporation) to conduct research on the molecular underpinnings and mechanisms of frontotemporal lobar degeneration (FTLD), which underlies frontotemporal dementia (FTD) and is associated with amyotrophic lateral sclerosis...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $1,938,189.00 to Emory University to conduct research on the mechanisms and toxicity of chimeric dipeptide repeat (DPR) proteins in C9ALS/FTD, a form of amyotrophic lateral sclerosis and frontotemporal dementia. The research aims to: 1) identify the complexity, extent, and mechanism of chimeric DPR pathology in C9ALS/FTD, 2) investigate the molecular consequences and neuronal toxicity of...
This $717,709 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to advance the understanding of tau protein aggregation and propagation in Alzheimer's disease (AD) and frontotemporal dementia (FTD). The awardee, Weill Medical College of Cornell University, will utilize advanced proteomic techniques, including affinity purification mass spectrometry and transcriptomic profiling, to map the molecular mechanisms underlying tau pathology in...
This federal Project Grant award, provided by the National Institute on Aging under CFDA Program 93.866 - Aging Research, aims to evaluate the therapeutic potential of CHCHD10 antagonists and elucidate the relationship between CHCHD10, mitochondrial-associated endoplasmic reticulum membranes (MAM), and mitophagy in the context of Alzheimer's disease (AD) pathogenesis. The $1,828,726 award to Case Western Reserve University will fund a 5-year research project to: (1) assess the protective effects...
This K01 project grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program provides $236,668 to support research at the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University. The objective is to elucidate how interactions between the C9ORF72-associated dipeptide repeat protein poly(GR) and the BAF chromatin remodeling...
The National Institute on Aging (NIA), under the Aging Research Federal Grant Program (CFDA 93.866), awarded a $350,001 Project Grant to the Icahn School of Medicine at Mount Sinai (ISMMS) to conduct research on the role of clonal hematopoiesis (CH) in neurodegenerative diseases. The key objectives of the project are to: 1) uncover the associations between different types of CH and neurodegenerative diseases like Alzheimer's, Parkinson's, Lewy body dementia, and ALS/FTD; 2) characterize the...
This $432,802 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research focused on identifying gene expression changes associated with the C9ORF72 mutation in frontotemporal dementia (FTD). The primary awardee, Pennsylvania State University (doing business as Penn State Milton S. Hershey Medical Center), will cross-validate...
The National Institute of Neurological Disorders and Stroke (NINDS), through the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853), has awarded a $869,959 Cooperative Agreement to The Regents of the University of California, San Francisco to develop a safe and effective genome editing therapy to treat frontotemporal dementia caused by the C9ORF72 gene mutation. The project aims to optimize a CRISPR/Cas9 genome editing strategy to excise the C9ORF72 repeat...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to characterize novel mixed etiology dementia models compromised for TDP-43 function. The $210,310 award, spanning from June 2024 to October 2026, will enable The Johns Hopkins University to develop mouse models exhibiting Alzheimer's disease, frontotemporal...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $442,750 to Case Western Reserve University (CWRU) to develop and experimentally model synthetic replicas of TDP-43 protein filaments associated with frontotemporal dementia and other neurodegenerative diseases. The goal is to generate in vitro amyloid fibrils that structurally match the TDP-43 filaments found in patient brains, as verified by high-resolution cryo-electron microscopy. This...

This R01 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $826,742 to Weill Medical College of Cornell University to conduct research on the molecular mechanisms and potential therapeutic strategies for frontotemporal dementia associated with mutations in the CHCHD10 gene.

The key objectives of this 5-year project are to: 1) elucidate the structural and molecular basis of CHCHD10 protein aggregation, including investigating whether distinct structural strains of CHCHD10 fibrils form in vitro versus in vivo models and human samples; 2) test the neuroprotective and systemic effects of antisense oligonucleotides targeting CHCHD10 in a mouse model of mutant CHCHD10-driven neurodegeneration; and 3) assess alterations in autophagy in the CHCHD10 mouse model and explore approaches to enhance autophagy to eliminate CHCHD10 aggregates. This multidisciplinary project leverages the complementary expertise of the principal investigators in modeling neurodegenerative diseases and protein structure/aggregation.

Generated 6/10/25, 5:38 AM