The federal Project Grant award R01NS133200, funded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research focused on identifying germline modifiers of tumors associated with Neurofibromatosis Type 1 (NF1). The total grant funding is $656,513, awarded on September 10, 2024, with a completion date of August 31, 2029. The research aims to expand the...
This $877,001 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program supports a research initiative aimed at elucidating the cellular and molecular mechanisms underlying the clinical heterogeneity observed in Neurofibromatosis Type 1 (NF1). Specifically, the project will leverage patient-derived induced pluripotent stem cells, primary...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, provides $190,485.00 to support a 5-year research project investigating the molecular mechanisms underlying differentiation failure in neuroepithelial stem cells with NF2 mutations. The goal is to identify the cellular origins of spinal ependymoma tumors in patients with NF2...
This $443,354 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports research to investigate novel therapeutic targets for diffuse midline gliomas (DMG), an aggressive pediatric brain tumor. The research aims to leverage unbiased approaches to identify vulnerabilities in the metabolic pathways of DMG cells harboring the H3K27M mutation, which...
This federal Project Grant award of $226,500.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program aims to characterize and treat peripheral nervous system dysfunction in Sanfilippo syndrome (mucopolysaccharidosis type IIIA). The key objectives are to: 1) Develop novel cellular models using patient-derived induced pluripotent stem cells to recapitulate peripheral...
The Department of Defense, through the Military Medical Research and Development program (CFDA 12.420), awarded a $858,033 Project Grant to the Children's Hospital Medical Center in Cincinnati, Ohio. The grant, titled "TARGETING SCHWANN CELL-IMMUNE INTERACTIONS IN NEUROFIBROMATOSIS TYPE 1", will fund research focused on improving treatment approaches for neurofibromatosis type 1, a genetic disorder that causes tumor growth in the nervous system. The grant award period runs from...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $676,388 to St. Jude Children's Research Hospital Inc. for research into the role of polarity signaling proteins in regulating chromatin organization and neuronal differentiation. The research aims to define how the proteins SIAH2 and PARD6A impact chromatin compaction...
This $460,940 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports research to investigate the impact of glioma-associated germline risk alleles on neurodevelopmental trajectories. The award to the University of Texas MD Anderson Cancer Center will leverage single cell and bulk profiling approaches in induced pluripotent stem cell...
This Project Grant award, valued at $897,250.00, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The grant supports a comprehensive research program at St. Jude Children's Research Hospital focused on understanding the fundamental mechanisms of biomolecular condensation and its role in neurological diseases. The research aims to...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $635,173 to support research on understanding the mechanisms by which the MYCN oncogene drives an immunosuppressive tumor microenvironment in high-risk neuroblastoma. The key products or services to be delivered under this grant include: Characterizing the types and...