This $275,100 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to investigate the structure and function of proteins involved in intracellular transport mechanisms within human cells. The research aims to reveal the mechanistic basis and functional implications of the specificity factors of the cytoplasmic dynein motor protein, as well as elucidate how the Olduvai...
The University of Colorado-Denver was awarded a $405,282 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The grant, awarded on September 5, 2024, supports research to investigate the role of antibodies targeting PLP1-anchored membrane domains in the pathogenesis of multiple sclerosis (MS). The key objectives include: Employing a...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, aims to develop a synthetic biological system to manipulate subcellular RNAs and proteins in growth cones or synapses of subtype- and context-specific neurons. The $481,250 award, spanning September 2024 to September 2026, will enable the researchers to integrate subcellular...
The University of North Dakota was awarded a $419,038 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The grant, which runs from September 17, 2024 to August 31, 2027, will fund the development of a miniature selective plane illumination fluorescence microscope for high-resolution volumetric imaging in freely behaving mice. This...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support research to understand the mechanism of action of small molecule splicing modulators for potential Huntington's disease therapy. The $195,000 award, spanning April 2025 to March 2027, will enable the University of Colorado-Denver to evaluate the feasibility of using...
This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) provides $422,280 to The Regents of the University of Colorado, doing business as the University of Colorado-Denver, to identify and study novel intracellular proteins that underlie the distinct nanoscopic architecture of the neurexin-1 and neurexin-3 proteins. The project aims to use super-resolution imaging techniques and structure-function analyses to...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $465,752 to the Regents of the University of Michigan - Dearborn to conduct research on understanding changes in cell chirality and cell-cell interactions within the neurovascular unit (NVU) after traumatic brain injury (TBI). The project aims to evaluate TBI-induced...
This Project Grant award of $429,000 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research to understand the cellular and synaptic mechanisms underlying cognitive disabilities in Down syndrome. The award to the University of Colorado-Denver will utilize a novel combination of two-photon microscopy, electrophysiology, chemogenetics, and pharmacological...
This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) provides $429,000.00 to The Regents of the University of Colorado, doing business as the University of Colorado-Denver, to develop and apply tools for manipulating biomolecular condensates in neurons in order to modulate the properties of the postsynaptic density and assess the functional consequences on synaptic structure and plasticity. The two-year project...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $503,439 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the University of Colorado-Denver to conduct research on the functional roles of inhibitory cerebellar outputs. This 4-year project aims to advance the understanding of how the cerebellum, a critical region for motor control, tunes its own teaching signals and actuates motor control through...