This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $676,748 to Brigham & Women's Hospital Inc. to explore strategies for treating and preventing neutropenia-related bacterial pneumonia. The key focus is on targeting the protein Gasdermin D (GSDMD) to prolong the survival of neutrophils, which are critical for defending against pathogens in the lungs of neutropenic patients....
This $262,098 federal Project Grant award, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to develop and characterize human induced pluripotent stem cell (iPSC)-derived neutrophil therapies against invasive pulmonary aspergillosis (IPA). The primary objectives are to: 1) assess the ability of iPSC-derived neutrophils to inhibit the growth of two common Aspergillus fungal...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $759,983 to the University of North Carolina at Chapel Hill to conduct research on the role of neutrophils in the immune response to bacterial pneumonia and acute lung injury. The key objectives are to examine changes in neutrophil transcriptomes and lung microenvironments during the development and resolution of Streptococcus...
This $838,320 federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) funds research to define the genetic determinants of Aspergillus fumigatus pathogenicity in the context of Bruton's tyrosine kinase (BTK) inhibitor cancer therapies. The research aims to uncover novel fungal factors that enable invasive aspergillosis in patients receiving BTK inhibitor treatments, which have been...
This Project Grant award of $1,220,472.00 from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) aims to study the use of adoptively transferred naive B cells to provide multi-organ protection in a mouse model of acute respiratory distress syndrome (ARDS) induced by hyperoxia. The key goals are to: Investigate the efficiency of B cell homing to the lungs and brain and characterize the phenotypes of B cells that traffic to these inflamed sites. Identify...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $194,740 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The Children's Hospital Corporation, doing business as Boston Children's Hospital. The purpose of this 5-year grant is to characterize the development of lung-resident self-antigen-specific regulatory T cells (Tregs) following acute lung injury in an experimental mouse model. The research aims to understand how these...
This federal Project Grant award for $373,500.00, funded by the National Heart Lung and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), will support a secondary analysis of existing datasets to define the neutrophil transcriptomic response to parenchymal damage. The research aims to identify and validate a targeted neutrophil gene expression program specific to parenchymal damage, define the dynamic expression of this program in the development of...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $1,063,324 to Tulane University from June 5, 2025 to May 31, 2032. The funded research project aims to advance understanding of CD4+ T cell immunity in the respiratory tract, with a focus on mechanisms underlying host defense against extracellular pathogens and the role of type 17 cytokines and tissue-resident memory CD4+ T cells....
This federal Project Grant award of $249,000 from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), supports the development of methodologies to reveal the role of the blood microbiome in the gut-lung axis for asthma pathogenesis. The research aims to develop a computational pipeline for reduced metagenomic sequencing to profile the blood microbiome, and a deep learning framework to optimize diagnosis and prediction models...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $760,759 to the University of Illinois to study the immunoregulatory role of a specific dendritic cell subset, CX3CR1+CDC2, in resolving allergic lung inflammation associated with asthma. The key objectives are to characterize the anti-inflammatory functions of the CX3CR1+CDC2 subset, determine how it regulates T regulatory cell...