The federal Project Grant award R01AI191067 in the amount of $838,320 was awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant supports research conducted by Trustees of Dartmouth College to investigate fungal pathogenicity determinants and their impact on invasive aspergillosis infections, particularly in the context of cancer therapies that inhibit Bruton's tyrosine kinase. The researchers aim to define the genetic network responsible for Aspergillus fumigatus susceptibility to neutrophil-mediated killing and identify key pathogenicity factors in clinical isolates from patients undergoing Bruton's tyrosine kinase inhibitor therapy. This work is expected to reveal novel fungal pathogenicity mechanisms relevant to precision medicine approaches in the clinical treatment of cancer.
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