Project Grant R03HL173070
- This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $708,063 in funding to the University of Virginia for a research project titled "Post-Transcriptional Regulatory Networks in Chronic Obstructive Pulmonary Disease". The goal of the 5-year project is to generate RNA-binding protein (RBP) regulatory networks, identify COPD-specific changes, and characterize the functional consequences of the network changes....
- This federal Project Grant award of $805,921 from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) aims to integrate multi-trait, multi-ancestry, and multi-omic data from massive global biobanks to decipher the genetic mechanisms underlying respiratory diseases like chronic obstructive pulmonary disease (COPD) and asthma. The award, with a performance period from September 2025 to June 2030, will leverage data from over 2 million participants,...
- This $234,000 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research by Thomas Jefferson University to characterize the expression pattern of circulating short non-coding RNAs (sncRNAs) as potential biomarkers for chronic obstructive pulmonary disease (COPD). The researchers will obtain plasma samples from the SPIROMICS study to quantify the levels of two specific sncRNAs, IMMR-Val and IMMR-His, that were previously...
- This $131,783 federal Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to Brigham & Women's Hospital Inc., a subsidiary of Partners Healthcare System, will fund a study to develop and implement a protocol for biospecimen collections before and after bronchoscopic lung volume reduction (BLVR) procedures in COPD patients. The goal is to identify blood and bronchoalveolar lavage fluid biomarkers associated with COPD phenotypes...
- This Project Grant award, provided by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837), will fund the development of novel computational methods to investigate the role of DNA methylation in the progression of Chronic Obstructive Pulmonary Disease (COPD). The $1,470,578 award, spanning from January 1, 2025 to December 31, 2028, will enable researchers at the University of Florida to assemble and analyze multi-omic data from large COPD...
- This Project Grant award of $762,867.00 from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) aims to investigate the role of the cofilin-1 protein in regulating mitochondrial function and quality control in airway epithelial cells. The research, conducted by The Johns Hopkins University, seeks to understand how the loss of cofilin-1 impacts mitochondrial dynamics and mitophagy, and how these processes contribute to airway epithelial dysfunction in...
- This Project Grant award of $800,679.00 from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) will support the University of Virginia's research to interrogate the pathogenesis of chronic obstructive pulmonary disease (COPD) using metabolomics and genomics data. The objective is to expand the PredixCan method to incorporate metabolomics data, creating a new tool called MetaBoxCan, in order to extract more comprehensive mechanistic information from...
- This federal Project Grant award, totaling $765,612.15, was provided by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research (CFDA 93.837) program. The award supports research to conduct a molecular analysis of airway secretory cells in the context of Chronic Obstructive Pulmonary Disease (COPD), the third leading cause of death in the U.S. and worldwide. The research, taking place at the Research Institute at Nationwide Children's Hospital in Columbus, Ohio,...
- The National Heart, Lung, and Blood Institute (NHLBI), a division of the National Institutes of Health (NIH), awarded a $189,000 Project Grant under CFDA #93.837 Cardiovascular Diseases Research program to the University of Colorado-Denver. The 2-year grant, with a period of performance from September 15, 2025 to August 31, 2027, will support research to investigate the role of outdoor air pollution and environmental allergens in driving treatment response in children with acute asthma...
- This Project Grant award of $258,516 from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) will fund research to better understand the role of mitochondrial-derived peptides (MDPs) in the development of chronic obstructive pulmonary disease (COPD). The University of Pittsburgh will utilize the NHLBI BIOLINCC repository to analyze plasma and lung tissue samples to characterize changes in MDPs across COPD disease severity. They will combine...
The National Heart Lung and Blood Institute (NHLBI), via the Cardiovascular Diseases Research federal grant program (CFDA 93.837), awarded a $222,750 project grant to the University of Alabama at Birmingham (UAB) to investigate genetic factors that influence susceptibility to frequent exacerbations in African American patients with chronic obstructive pulmonary disease (COPD). The key objectives are to: 1) Examine the interaction between specific variants in immunoglobulin G (IgG) and its receptor as a risk factor for severe COPD exacerbations in African American participants; and 2) Evaluate IgG3 hinge length as a mechanism for discordance between antibody levels and function in this population. The project will leverage longitudinal data from two large COPD cohort studies to advance scientific understanding of the genetic underpinnings of COPD exacerbations in this high-risk patient group. The award period spans from August 1, 2025 to July 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $222.8k | 7/30/25 |