Federal Project Grant Award Summary

Emory University received a $156,500 Project Grant from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), effective June 1, 2026, through May 31, 2028. The award funds investigator-initiated research examining the impact of chronic low-dose cadmium exposure on skeletal growth and maintenance in mouse models. The research will employ advanced imaging techniques, including high-resolution micro-computed tomography, histomorphometry analysis, biochemical bone turnover assessments, and bone strength/fracture resistance assays to evaluate cadmium's effects on the lumbar spine and femur during early skeletal development through peak bone density attainment.

This research addresses a significant public health concern by investigating environmentally relevant cadmium exposures during critical developmental periods at doses previously considered safe. The project will generate critical scientific data on how toxic heavy metal bioaccumulation compromises skeletal health and peak bone mass achievement, with direct implications for informing environmental safety standards and public health policy as cadmium exposure continues to rise globally. Findings will highlight the vulnerability of developing skeletal systems to environmental toxins and contribute to understanding mechanisms underlying osteoporosis prevention.