Project Grant R03HD112581

Award Date 8/8/23
Completion Date 7/31/25
Dollars Obligated $152K
Federal Grant Program
93.865
Assistance Type
Project Grant
Place of Performance
Raleigh, NC 27695, USA
Similar Awards
This federal Project Grant award for $226,500.00, provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research to elucidate the mechanisms by which the uterine epithelial estrogen receptor alpha (ERA) regulates the uterine immune environment during early pregnancy. The key objectives are to determine how uterine epithelial ERA temporally orchestrates the immune status...
This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $1,963,122 to the University of Missouri System to conduct research on the molecular mechanisms regulating uterus development. The research aims to define critical physiological and genetic pathways that govern uterine development, function, and regeneration in order to better diagnose,...
This federal Project Grant award, valued at $526,008.00, was issued by the National Institute of Child Health and Human Development under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant supports research to investigate the role of the METTL3 gene in mammalian placenta development and maintenance across pregnancy, with a focus on understanding how alterations in METTL3 function may contribute to pregnancy-associated disorders like intrauterine growth...
This federal Project Grant award R01HD112559, totaling $1,887,823.00, was provided by the National Institute of Child Health and Human Development under the Child Health and Human Development Extramural Research program (CFDA 93.865). The award supports a research project investigating the regulation of trophoblast cell development, which is critical for successful pregnancy establishment. The research aims to elucidate the roles of the activin-follistatin like 3 and WNT-WNT antagonist...
This federal Project Grant award, valued at $1,080,375 and spanning July 2024 to March 2029, was provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The award supports research aimed at defining how the maternal load is established during oogenesis and decoded after fertilization, with a focus on understanding the regulatory mechanisms and environmental factors that impact...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD), CFDA 93.865 Child Health and Human Development Extramural Research program, will provide $397,375.00 to the University of Wyoming to conduct laboratory research on the role of PGRMC proteins as potential markers of fertility and overall health status. The research aims to evaluate PGRMC1 and PGRMC2 gene expression across the lifespan in major organs, and to examine the impact of selectively...
This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) provides $153,656 to Baylor College of Medicine to investigate the role of iron homeostasis and ferroptosis in endometriosis and early pregnancy outcomes. The research aims to characterize how the iron export protein SLC40A1 influences iron dynamics, oxidative stress, and lipid peroxidation during...
This Project Grant award from the National Institutes of Health's (NIH) National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) provides $130,680 to the University of Kansas Medical Center Research Institute (KUMCRI) to investigate the regulatory mechanisms underlying the differentiation of extravillous trophoblast (EVT) cells from human trophoblast stem (TS) cells. The key objectives of the research are to: 1) Deplete the...
The University of Illinois has received a $655,014 Project Grant award from the National Institute of Child Health and Human Development under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant will fund research to determine if glycogen stores in the uterine endometrium are necessary for successful pregnancy. The project aims to 1) knockout glycogen synthase in the uterus of mice to assess the impact on fertility and pregnancy, and 2) elucidate the...
This federal Project Grant award from the National Institute of Child Health and Human Development under the Child Health and Human Development Extramural Research program (CFDA 93.865) provides $2,018,716 in funding to the University of Georgia Research Foundation to investigate the mechanisms of uterine fluid absorption during early pregnancy. The project aims to determine the in vivo functions and regulatory mechanisms of key ion and water channels in the uterine epithelium that control...

This Federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), will provide $152,000.00 to North Carolina State University (NC State) for research on the role of the TET2 enzyme in regulating uterine function and fertility.

The primary objectives are to determine the in vivo role of TET2 in: 1) regulation of the uterine window of receptivity, and 2) endometrial stromal cell decidualization, which are critical processes for embryo implantation and pregnancy. This research will utilize conditional TET2 knockout mouse models to investigate the epigenetic mechanisms by which TET2 regulates normal uterine physiology, as well as its potential dysregulation in conditions like endometriosis and endometrial cancer. The project will run from August 2023 through July 2025, with the goal of informing future human clinical research in reproductive health.

Generated 7/16/24, 10:06 AM