Project Grant R03ES035972
Award Date
9/13/24
Completion Date
8/31/26
Dollars Obligated
$157K
Federal Agency
National Institute of Environmental Health Sciences
Federal Grant Program
93.113
Assistance Type
Project Grant
Place of Performance
Honolulu, HI 96813, USA
Similar Awards
This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), aims to create an in vitro yolk sac model, or yolk sac organoid, using human pluripotent stem cells. The $156,500 award, effective from April 15, 2025 to March 31, 2027, will support the University of Hawaii at Manoa in characterizing the stem cell-derived cysts, evaluating their...
The National Institute of Child Health and Human Development (NICHD) awarded a $411,125 Project Grant (CFDA 93.865 - Child Health and Human Development Extramural Research) to Syracuse University to develop a microfluidic human placenta organoid model. The goal is to generate human trophoblast stem cells (HTSCs) from induced pluripotent stem cells and use them to create a placenta organoid system that can replicate early/mid-gestation placental development. The researchers will study the role of...
This federal Project Grant award of $421,067.00, awarded by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), will fund research using kidney organoids to investigate the effects of in utero exposures, such as pregestational diabetes, on kidney development programs. The research aims to identify alterations to the normal differentiation of nephron progenitors and podocytes within the kidney...
This $453,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to define the molecular mechanisms and cellular dynamics required to assemble a functional stem cell niche during embryonic development. The research, conducted at East Carolina University, aims to elucidate the signaling pathways, transcriptional regulators, and cytoskeletal processes that guide the migration and...
This federal Project Grant award for $152,816.00, provided by the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research), aims to investigate the link between Down's syndrome (trisomy 21) and placentation defects. The research will focus on: Identifying transcriptional differences in implantation-stage trophoblasts between trisomy 21 and euploid induced pluripotent stem cell lines through RNA-sequencing. Assessing the...
Yale University was awarded a $3,015,000 Project Grant from the Department of Health and Human Services National Institutes of Health Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) for the period of September 15, 2022 through August 31, 2025. The grant will support research to develop a controllable and scalable in vitro model for studying human embryonic patterning and germ layer differentiation using human pluripotent stem cells and bioengineering...
This Project Grant award of $147,486, provided by the National Institute of Child Health and Human Development (NICHD) under CFDA Program 93.865 - Child Health and Human Development Extramural Research, aims to investigate the role of the placenta-brain axis in Down Syndrome (DS) development. The research, conducted by The Johns Hopkins University, will examine how increased dosage of human chromosome 21 genes, specifically APP and SOD1, impact placental function and the secretion of neuroactive...
This National Science Foundation (NSF) Engineering (CFDA 47.041) Project Grant award to Worcester Polytechnic Institute (WPI) in the amount of $259,570 will develop 3D spheroid models using patient-derived trophoblast cells to investigate placental cell invasion and study preeclampsia, a pregnancy complication with high global maternal and infant mortality rates. The 2-year project will design culture conditions to maintain the spheroid models, engineer an extracellular matrix to mimic the...
This federal Project Grant award for $378,123 from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) supports research to identify and test mechanisms that establish transcriptional regulatory potency in early embryos. The primary activities include using genomic methods like PRO-seq, DREG, and OMNI-ATAC to characterize transcriptionally active regulatory elements, DNA accessibility, and...
This Project Grant award of $659,574, provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research to understand how the signaling system of Nodal and its inhibitors, cofactors, and coreceptors functions in patterning during early human embryonic development. The research, conducted at William Marsh Rice University, leverages CRISPR editing of human pluripotent stem cells...