Project Grant R03DK149619
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Vanderbilt University $118,875 on May 14, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate metabolic plasticity in the kidney during obesity and acute kidney injury. The research, titled "Factors Controlling Metabolic Plasticity in the Kidney During Obesity and Injury," examines how obesity-induced insulin resistance desensitizes the metabolic...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Vanderbilt University $140,396 on December 13, 2025, for research investigating the role of PDX1 C-terminal interaction domains during pancreatic endocrine differentiation and proliferation under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The research examines how the homeobox transcription factor PDX1 regulates insulin-producing beta cell development and proliferation in the...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Vanderbilt University Medical Center $354,714 on September 9, 2025, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to conduct a pilot Phase II open-label clinical trial investigating adjuvant tirzepatide (TRZ) therapy in post-bariatric surgery patients. The research addresses a critical gap in obesity treatment. While gastric bypass surgery remains the most effective obesity...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Pittsburgh $735,900 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to research electronic consultation (eConsult) practices for pediatric obesity care. The award funds a five-year investigation (through May 31, 2031) into best practices for asynchronous subspecialty consultation in pediatric obesity management, with focus on...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Yale University $839,770 on June 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to support cognitive and behavioral approaches to reduce binge eating and excess weight in adolescents. The award is a Project Grant with a period of performance extending through February 28, 2031, and work is performed in New Haven, Connecticut. The program promotes extramural basic...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded The Leland Stanford Junior University $782,886 on February 18, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to support research on obesity control through an appetite-suppressing peptide. The research addresses the urgent need for new metabolies, including obesity and associated metabolic disorders. Work is performed in Palo Alto, California with a period of...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Vanderbilt University $149,190 on September 15, 2025, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to develop computer vision models that quantify and remove visual impairments during endoscopic kidney stone surgery. The project addresses the high rate of repeat stone procedures caused by residual stone fragments after initial surgery. Blood and debris frequently obscure...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Vanderbilt University Medical Center $175,000 on May 20, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to conduct spatial profiling of pancreatic N-glycosylation in type 1 diabetes. The research employs state-of-the-art imaging technologies to map how protein N-glycosylation—the enzymatic attachment of complex carbohydrate chains to asparagine residues on...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Vanderbilt University Medical Center $146,248 on June 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to adapt a diabetes self-management support intervention for adults with cognitive dysfunction. The award funds development of a technology-delivered intervention integrating evidence-based rehabilitation methods to support diabetes management in adults with type 2...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded The Children's Hospital Corporation, doing business as Boston Children's Hospital, $167,060 on August 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847, Project Grant K08DK143340). The award funds research on defective STAT3 signaling in very early-onset inflammatory bowel disease patients, with the objective of linking molecular pathways to precision-based...
The National Institute of Diabetes and Digestive and Kidney Diseases awarded Vanderbilt University Medical Center $158,158 on August 15, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to support a research project examining guideline-concordant pediatric obesity care in outpatient pediatric clinics. The award funds Dr. Colin Orr's research using the Science, Technology, and Research (STAR) and PEDSnet clinical research networks to create a national dataset of children with obesity, establish the current landscape of guideline-concordant care delivery, and conduct a mixed-methods implementation science study of patients, parents, and clinic staff to identify barriers and facilitators to obesity management and treatment. The research builds on Dr. Orr's prior K23 career development award from NIDDK focused on preventing pediatric obesity through the Peer Parent Coach Community Collaboration (P2C3) intervention, which targets drivers of unhealthy infant weight gain including inconsistent food access, maternal mental health, and parental knowledge of growth and nutrition. The R03 project grant advances his professional development by expanding his research network, developing content expertise in obesity management and treatment, and providing mentored experience in implementation science methodology guided by the Consolidated Framework for Implementation Science Research. Work is performed at Vanderbilt University Medical Center in Forest Hills, Tennessee, with performance through July 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $158.2k | 8/12/26 |