Project Grant R03DK144246
- Federal Project Grant Award Summary Seattle Children's Research Institute received a $724,950 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective May 15, 2026, with completion targeted for March 31, 2030. The award supports basic biomedical research aimed at understanding and improving the reprogramming of human fibroblasts into induced...
- Federal Grant Award Summary The National Cancer Institute awarded Fred Hutchinson Cancer Center a $739,640 Project Grant under the Cancer Detection and Diagnosis Research program (CFDA 93.394) for the period September 1, 2025, through August 31, 2030. This award supports the development and validation of methods to advance early detection of pancreatic ductal adenocarcinoma (PDAC) by leveraging electronic medical records (EMR) data. The project addresses the critical public health challenge that...
- Federal Project Grant Award Summary Fred Hutchinson Cancer Center received a $129,708 Project Grant award from the National Institute of General Medical Sciences under the Biomedical Research and Research Training program (CFDA 93.859) for the period August 1, 2025 through July 31, 2026. The award supports the development of computational tools and methodologies for analyzing single-cell molecular data to advance understanding of cellular differentiation and cancer progression. Specifically, the...
- Federal Project Grant Award Summary Fred Hutchinson Cancer Center received a $776,511 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded September 1, 2025, with completion targeted for May 31, 2029. This award supports research to develop and validate a three-dimensional engineered hemogenic vascular niche model designed to elucidate the microenvironmental factors that promote hematopoietic stem...
- Federal Project Grant Award Summary The University of Washington received a $654,536 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective April 15, 2026, with a completion date of January 31, 2031. This research project investigates the pathogenic mechanisms of neutrophil elastase (NE) mutations in hereditary neutropenia, specifically severe...
- Federal Project Grant Award Summary Fred Hutchinson Cancer Center received a $226,404 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) on June 22, 2026. The award funds research into deconvoluting the disparate roles of DDX6 (a DEAD-box RNA helicase protein) in translational control, with a completion date of February 28, 2029. The project will employ biochemical, single-molecule, and...
- Federal Project Grant Award Summary Award Details: Fred Hutchinson Cancer Center received a $613,838 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award, effective March 1, 2026, through February 28, 2031, supports fundamental research into the mechanisms governing dynamic interactions between cellular membranes and the cortical cytoskeleton. Research Scope: The project focuses on...
- Federal Grant Award Summary Boston Children's Hospital received a $469,042 Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective September 1, 2025, through August 31, 2027. The award supports the transformation and optimization of a human induced pluripotent stem cell (iPSC)-derived bone marrow organoid platform for advanced hematopoiesis research. The...
- Federal Project Grant Award Summary Albert Einstein College of Medicine received a $829,319 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective February 1, 2026, with completion targeted for November 30, 2030. The award supports basic biomedical research investigating the collaborative factors driving DDX41 (ataxia telangiectasia and...
- Federal Grant Award Summary The University of Washington received a $192,763 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective March 1, 2026, with completion targeted for November 30, 2030. This award supports investigator-initiated biomedical research designed to advance understanding of the mechanisms underlying cirrhosis-related kidney...
Fred Hutchinson Cancer Center received a $132,000 Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), awarded May 20, 2026, with completion targeted for March 31, 2028. The grant funds research to elucidate how mesenchymal stromal cell (MSC)-derived syndecan-2, a heparan sulfate proteoglycan, regulates hematopoiesis in vivo through a multi-scale approach examining molecular, cellular, and systemic functions. This investigation builds on preliminary findings that genetic depletion of syndecan-2 in MSCs caused significant hematopoietic system imbalances, with the objective of generating therapeutics that can correct or support hematopoietic regeneration during disease or stress. The research addresses a critical clinical need, as understanding fundamental hematopoietic processes is essential for developing interventions that restore hematopoietic homeostasis following radiation and chemotherapy exposure. The work is positioned to advance basic knowledge of bone marrow niche regulation and inform therapeutic strategies to mitigate hematopoietic insufficiency complications such as infection or hemorrhage in vulnerable patient populations. Research activities are being conducted at Fred Hutchinson Cancer Center's Seattle, Washington facility.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $132.0k | 5/22/26 |