Project Grant R03DK142030
- This Project Grant award for $194,380, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to study the role of the protein LIM-nebulette in maintaining the structural integrity of podocytes, which are specialized kidney cells. The research project, conducted by the Icahn School of Medicine at Mount Sinai, will utilize a novel mechanical stretch platform and...
- This $146,829 Project Grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to investigate the molecular mechanisms by which the bacterial protein BEFA (beta-cell expansion factor A) induces the proliferation and metabolic maturation of pancreatic beta cells. The research, conducted at the University of Oregon, utilizes single-cell imaging, genetic...
- This federal Project Grant award, with a total funding amount of $645,617, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant is aimed at understanding the dysfunction of hematopoietic stem cells in refractory Crohn's disease, a condition that is resistant to traditional treatments. The research will profile hematopoietic stem cell populations...
- This federal Project Grant award of $169,000.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant was awarded to the Icahn School of Medicine at Mount Sinai in New York, NY to conduct a research project titled "Defining the Contributions of Amygdalar Circuits to the Metabolic Responses to Homeostatic Challenge." The overarching goal is to...
- This $681,562 Project Grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) aims to investigate approaches for enhancing the metabolic maturity and functionality of human pluripotent stem cell-derived islet organoids, with the goal of improving their survival and efficacy for transplantation as a treatment for type 1 diabetes. The research will examine the use of pharmacological agents...
- This federal Project Grant award of $641,794 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant aims to elucidate the mechanisms that protect beta-cells from DNA damage during periods of growth and adaptation, in order to maintain beta-cell homeostasis and prevent the loss of functional beta-cells, a key factor in the development of type 1 and type 2...
- This $3,140,632 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research program) aims to elucidate the mechanisms underlying human endocrine lineage commitment and harness this knowledge to improve strategies for beta cell replacement in diabetes treatment. The 4-year project, awarded to the Regents of the University of California, San Francisco, seeks to enhance the...
- This federal Project Grant award of $801,662, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research by the Scripps Research Institute to investigate the early phase of type 1 diabetes. The key objectives are to characterize the antigen-presenting cells associated with pancreatic islets during the pre-diabetic stage in mice, using advanced techniques...
- This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) provides $138,753 to The Washington University to support research on cytoskeletal regulation of gut tube organogenesis and subsequent maturation of stem cell-derived islets. The goal is to enable a cell-based therapy to become a viable and widely-used treatment option for type 1 diabetes, which results from the autoimmune destruction of insulin-producing beta cells. The research will...
- This federal Project Grant award of $208,428, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research), aims to enhance the safety and efficacy of stem cell-derived islet transplantation for treating type 1 diabetes. The key objectives are to improve the survival and engraftment of the transplanted cells, enable long-term insulin independence, and develop safety mechanisms to retrieve the graft...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $253,500.00 to the Icahn School of Medicine at Mount Sinai to conduct longitudinal single-cell analyses of human islet organoids in response to beta cell regenerative drug therapies. The research aims to elucidate the temporal dynamics and mechanisms by which drugs like harmine, alone or combined with GLP1 receptor agonists, enhance human beta cell regeneration. The project will employ single-cell and single-nucleus RNA sequencing as well as single-nuclear ATAC sequencing to explore the evolution of cellular processes underlying beta cell expansion following regenerative drug treatment in this in vitro human islet organoid model. The award period runs from August 21, 2025 to June 30, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $253.5k | 8/29/25 |