This federal Project Grant award of $117,000 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports a systems biology research project conducted by the Regents of the University of Michigan. The key objectives are to: 1) Validate predicted transcription factor binding motifs related to the hypoxia-inducible factor 1-alpha (HIF1A) in areas of open chromatin using multiomics data, and 2)...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $168,886.00 to The University of Texas Southwestern Medical Center (UT Southwestern) to conduct research titled "Elucidating the Role of NAD+ and PARylation in Nephron Endowment." The award aims to study how maternal availability of nicotinamide adenine dinucleotide...
This $199,990 Project Grant award was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research at The Ohio State University to investigate the role of the transcriptional corepressor CTBP2 as a metabolic sensor in acute kidney injury (AKI). The key objectives are to: 1) examine how acetylation regulates the nuclear localization and activation...
This $1,149,974 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research to investigate the central role of red blood cell (RBC) trapping in mediating ischemic acute kidney injury (AKI). The primary awardee, Augusta University Research Institute, Inc., will conduct studies to test the hypotheses that RBC trapping induces tubular injury and heme toxicity, leading...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) is funding research to develop a therapeutic approach using dicarboxylic acids (DCAs) to prevent and treat acute kidney injury (AKI) and limit progression to chronic kidney disease (CKD). The $645,599 award to the University of Pittsburgh is supporting preclinical studies in animal models...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) provides $155,562 to investigate the effects of activating branched-chain amino acid (BCAA) catabolism on acute kidney injury (AKI) and the progression to kidney fibrosis. The award recipient, The Research Foundation for the State University of New York, doing business as Stony Brook University, will use advanced...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) provides $214,958 to The Washington University in St. Louis to conduct research on the role of Interferon-Stimulated Gene 15 (ISG15) as a regulator of cell death during acute kidney injury. The key objectives are to: 1) Determine the extent of kidney epithelial damage, magnitude and timing of necroptosis, and...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research program, will support a translational research study to investigate the role of the gut microbiome in the pathogenesis of sepsis-associated acute kidney injury (AKI). The $126,846 award, effective December 24, 2024 through June 30, 2026, will enable the principal investigator at the University of Michigan to: 1)...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $1,439,769 project grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to the University of Southern California. This 5-year study, titled "PFAS Exposure and Diabetic Kidney Disease in Youth with Type 2 Diabetes: A Multi-Omic Approach for Prevention and Treatment," aims to investigate the link between exposure to per- and polyfluoroalkyl substances...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) will provide $596,345 to Augusta University Research Institute, Inc. (doing business as Georgia Health Sciences) to investigate the molecular mechanisms underlying diabetic renal hypertrophy and its impact on acute kidney injury (AKI) susceptibility and severity in diabetes. The key objectives are to: (1) determine...