Project Grant R03DE035519
- Federal Project Grant Award Summary The University of Iowa received a $295,856 Project Grant from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), awarded July 15, 2025, with a completion date of July 14, 2027. This research initiative focuses on identifying rare genetic variants associated with orofacial clefts (OFCs), the most common birth defects affecting the head and neck. The project will deliver...
- Federal Project Grant Award Summary The University of Iowa received a $961,680 Project Grant from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), awarded May 8, 2025, with completion anticipated by May 7, 2027. This research grant supports an investigator-initiated study examining the role of Iroquois Homeobox 1 (IRX1) in regulating oral tissue repair and maintenance, specifically focusing on gingival...
- Federal Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded The University of Iowa a $311,000 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121), effective July 15, 2025, through July 14, 2027. This research initiative investigates the mechanisms underlying wedge-shaped noncarious cervical lesions (NCCLs), a prevalent dental condition affecting up to 85% of adults in certain populations. The project delivers fundamental...
- Federal Project Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded The University of Iowa a Project Grant of $407,719 on July 15, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121). This longitudinal research study will investigate the impact of a self-determination theory (SDT)-based psychoeducational intervention on oral microbiome composition and early childhood caries (ECC) prevention in children from birth to three years of...
- Federal Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded The University of Iowa $1.398 million in Project Grant funding under the Oral Diseases and Disorders Research program (CFDA 93.121) on January 15, 2026, with a completion date of December 31, 2030. This longitudinal systems biology research initiative examines the mechanisms linking metabolic syndrome (METS) to oral microbiome dysbiosis and periodontal disease progression. The project will...
- Federal Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded the University of Illinois a Project Grant of $217,100.00 under the Oral Diseases and Disorders Research program (CFDA 93.121) effective March 1, 2030. This award supports a structured training and research initiative designed to develop the applicant as a clinician-scientist in craniofacial and oral sciences. The program delivers mentoring, career development support, and professional...
- Federal Grant Award Summary The Stowers Institute for Medical Research received a $371,250 Project Grant from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), awarded March 1, 2026, with completion scheduled for February 28, 2031. This five-year project focuses on investigating the pathogenesis, phenotypic variation, and prevention strategies for craniofacial anomalies, including conditions such as cleft...
- Federal Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded University of California Irvine $128,191 under the Oral Diseases and Disorders Research program (CFDA 93.121) for the period May 1, 2026 through April 30, 2028. The project, "Identifying Non-Coding Sources of Mammalian Craniofacial Variation," aims to advance understanding of genetic mechanisms underlying craniofacial variations and anomalies by identifying and functionally testing...
- Federal Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded a Project Grant of $1 to The Johns Hopkins University on September 18, 2025, under the Oral Diseases and Disorders Research program (CFDA 93.121). The grant supports research on generalizing genome editing approaches to treat rare disease-causing genetic variants through the completion date of August 31, 2028. The project develops broadly applicable editing strategies using base editing and...
- Federal Grant Award Summary Baylor College of Medicine received a $100,676 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), effective December 13, 2025, with an ultimate completion date of November 30, 2027. The award funds research investigating the molecular etiology of Keratinocyte Differentiation Factor 1 (KDF1), a disease gene associated with ectodermal dysplasia and tooth...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded The University of Iowa a $311,000 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) for the period July 9, 2026 through July 8, 2028. The award supports research into the functional analysis of genetic-epigenetic interplay in orofacial clefts (OFCs), the most common craniofacial birth defect affecting approximately 1 in 700 individuals worldwide. The research project aims to elucidate the role of differential DNA methylation (DNAm) and its interaction with genetic variation in OFC etiology, with the hypothesis that aberrant DNAm and resulting alterations in gene expression play a key role in OFC development, and that certain common genetic variants affecting OFC risk do so by influencing DNAm patterns. The deliverables under this grant will include functional studies and research findings examining how DNA methylation contributes to phenotypic variability in orofacial cleft patients, including investigation of methylation quantitative loci (meQTLs) that represent the intersection of genetic and epigenetic factors. The research will generate evidence regarding the role of differentially methylated regions in OFC pathogenesis and their association with genes involved in palatogenesis, thereby addressing gaps in the current understanding of OFC etiology and contributing to improved understanding of this complex craniofacial disorder.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $311.0k | 7/14/26 |