This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $1,766,868 to The University of Texas at El Paso to validate a computational neurobiological model of costly drug-taking behavior centered on the striosomes of the dorsomedial striatum. The project aims to experimentally determine the role of the prelimbic-striosomal and striosomal-substantia nigra circuits in mediating the impact of craving on...
This Project Grant award of $1,073,250.00 from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), is funding research to investigate how the middle-aged adult developmental stage may influence opioid reward and addiction. The key objectives of this research project are to: 1) determine any age-related differences in the involuntary effects of opioids on locomotion, nociception and thermoregulation, 2) use rat models of intravenous...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), is providing $226,295.00 to the University of Texas at Austin to conduct research on the mechanisms by which cocaine affects striatal circuit activity and cocaine seeking behaviors. The research aims to: 1) Determine the necessity of striatal enkephalin in cocaine-induced adaptations in the striatopallidal circuit, by investigating how...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $118,656 to the Ponce Medical School Foundation Inc. in Puerto Rico. The funding will support research to investigate the influence of fear conditioning and cocaine exposure on cocaine-seeking behavior in adult rats, with a focus on analyzing the neurophysiological changes in the prelimbic cortex-nucleus accumbens core circuitry. The project aims...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), will support a $346,911 cross-species research study to identify early life environmental and genetic risk factors for substance use disorders (SUDs). The key objectives are to: 1) determine how early life environment influences neurocognitive development and its relationship to adult impulsivity behaviors; 2) identify genomic networks associated...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $127,635 to the Regents of the University of Michigan to investigate the role of the glucocorticoid receptor as a neuromolecular mechanism regulating impulsivity and reward sensitivity. The research aims to determine if heightened reward sensitivity and rash impulsivity share a common neural pathway involving the prelimbic cortex and nucleus...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $818,513.00 to investigate the role of dopamine signaling in the basolateral amygdala on individual differences in reward-learning strategies and addiction-like behaviors. The 5-year study, starting on September 15, 2024, will focus on how Pavlovian reward-learning strategies, such as sign tracking versus goal tracking, predict unique...
This Project Grant award from the National Institute on Drug Abuse (CFDA 93.279 - Drug Use and Addiction Research Programs) provides $222,254 to the University of California, Irvine to examine the effects of psychedelic 5-HT2A agonist drugs, DOI and psilocybin, on aberrant reward-seeking behavior in an established rat model of early-life adversity. The goal is to determine the effective dose range of these psychedelic drugs and investigate their ability to reverse anhedonia (reduced pleasure...
This Project Grant award, provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), supports a randomized clinical trial to evaluate the effectiveness of cognitive skills training interventions in improving outcomes for offenders with substance use disorders. The $3,226,170 award, with a project period from September 30, 2024 to May 31, 2029, aims to validate prior findings that matching specific cognitive-emotional deficits in...
This Project Grant award of $207,910 from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), supports a 3-year training program for a graduate student at the University of Michigan to research shared neurobiological mechanisms that can confer vulnerability to addiction and comorbid psychiatric disorders such as post-traumatic stress disorder. The project will utilize chemogenetic and fiber photometry techniques to examine the...