This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $157,568 to Drexel University to elucidate corticolimbic circuit and neuroimmune mechanisms underlying HIV-induced dysregulation of reward-seeking behavior. The research aims to use optogenetic and chemogenetic techniques to stimulate the infralimbic cortex-nucleus accumbens shell circuit and modulate microglial function to rescue HIV-induced...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $146,922.00 to The Johns Hopkins University to conduct research on "ENDOCANNABINOID MODULATION OF THE HIV-INDUCED MICROGLIAL INFLAMMATORY RESPONSE." The award, which begins on Dec 17, 2024 and is scheduled for completion by Jun 16, 2026, will support scientific investigations into the potential role of the endocannabinoid system in...
This $181,675 federal Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) will support research to investigate the mechanisms by which nicotinic acetylcholine receptor (nAChR) signaling influences the maturation of excitatory synapses in the developing prefrontal cortex. The research aims to elucidate how endogenous cholinergic activity and nicotine exposure modulate excitatory synapse development, with the goal of...
This Project Grant award in the amount of $983,672.00 was issued by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279). The award will fund research to characterize the in-situ spatial interactions between HIV-infected cells and immune cells in the central nervous system (CNS) of people living with HIV, with a focus on understanding the impact of methamphetamine use on neuroinflammation. The research will leverage a unique cohort of brain...
This federal Project Grant award for $263,119 from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) is focused on developing NLRP3 inhibitors to address HIV-associated neuroinflammation in cocaine use. The key objectives are to computationally design, synthesize, and screen novel analogues of a lead compound, AMS-17, to improve its biological activity and maintain low toxicity. The project involves in vitro and in vivo screening of...
This $1,372,480 federal Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) supports research to elucidate the molecular mechanisms by which HIV Tat protein, cocaine, and combination antiretroviral therapy (cART) contribute to microglial pyroptosis and neuroinflammation in the context of HIV-associated neurocognitive disorders (HAND). The key objectives are to 1) determine the molecular mechanisms underlying...
This $2,223,769 Project Grant awarded by the National Institute on Drug Abuse (NIDA) under CFDA 93.279 - Drug Use and Addiction Research Programs aims to uncover the intersection between HIV infection and opioid use in driving neuroinflammation and neurotoxicity. The University of California, San Diego (UCSD) will lead a comprehensive research effort using archived and fresh human brain tissue specimens to: Determine the relationship between HIV activity, opioid exposure, and inflammasome...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $1,032,192 to Yale University to conduct research on the cell-type specific epigenomic effects of cannabis use in people living with HIV. The project aims to dissect the interactions between HIV infection and cannabis use, and identify potential druggable targets through comprehensive profiling of DNA methylation across different cell types. The...
This federal Project Grant award, funded by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research to examine the link between epigenetic processes, mitochondrial function, and drug-seeking behavior in the context of nicotine use disorder. The award, totaling $169,474.00 and spanning August 2024 to July 2029, will be carried out by researchers at the University of Maryland, Baltimore. The key objectives of this research...
This Project Grant award of $234,000.00 from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) will fund research to understand the impact of opioids on HIV transcription and latency. The research will utilize a novel dual fluorescent and bioluminescent HIV virus to visualize and measure the effects of opioids like fentanyl, morphine, and methadone on HIV proviral transcription in microglia and astrocytes. The goal is to identify key...