Project Grant R03CA297320
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded The Johns Hopkins University a Project Grant of $644,632 under the Cancer Treatment Research program (CFDA 93.395) effective May 1, 2026 through April 30, 2031. The research project focuses on developing novel antibody-drug conjugates (ADCs) targeting gamma-delta T-cell cancers, which affect approximately 1,000 patients annually in the United States. The primary objective is to establish a mechanistic link between genomic...
- Federal Grant Award Summary The National Cancer Institute awarded Johns Hopkins University a $591,419 project grant under the Cancer Treatment Research program (CFDA 93.395) effective May 1, 2026 through April 30, 2031. The award supports the development of low molecular weight theranostics targeting multiple myeloma, a disease characterized by malignant plasma cell expansion in the bone marrow. The research addresses critical gaps in treating therapy-resistant myeloma by developing a...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded The Johns Hopkins University a $399,129 Project Grant under the Cancer Treatment Research program (CFDA 93.395) on July 15, 2025, with a completion date of June 30, 2027. This award supports research to develop and evaluate improved cancer treatment methods through laboratory and clinical investigation. Specifically, the research leverages a DDX3 inhibitor called RK-33 to alter the metabolic tumor environment in...
- Federal Grant Award Summary The National Cancer Institute awarded The Johns Hopkins University a $643,861 Project Grant under the Cancer Cause and Prevention Research program (CFDA 93.393) effective June 1, 2026 through May 31, 2031 to conduct research investigating the molecular mechanisms of fusion oncoprotein condensates in translocation renal cell carcinoma (TRCC). The research focuses on understanding how TFE3 (Microphthalmia-associated Transcriptional Factor) fusion oncoproteins,...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded Johns Hopkins University a $144,193 Project Grant under the Cancer Detection and Diagnosis Research program (CFDA 93.394) effective September 4, 2025 through August 31, 2030. This award provides protected salary support for Dr. Preethi Korangath to serve as a Laboratory Research Specialist in Dr. Robert Ivkov's laboratory, where she will facilitate the completion of Research Project Grants (R01) by leveraging her expertise...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded The Johns Hopkins University a Project Grant totaling $162,080 under the Cancer Research Manpower program (CFDA 93.398) on December 27, 2025, with a completion date of June 30, 2028. Dr. Komatsu's laboratory is conducting research to visualize and characterize B cell infiltration and aggregation within the tumor microenvironment, with particular focus on the role of high endothelial venules (HEVs) as critical gateways for...
- Federal Grant Award Summary The National Cancer Institute awarded a $736,168 Project Grant to Sloan-Kettering Institute for Cancer Research (award date: August 1, 2025; completion date: July 31, 2030) under the Cancer Treatment Research program (CFDA 93.395) to develop novel antibody-drug conjugates (ADCs) and antibody-oligonucleotide conjugates (AOCs) designed to enhance radiotherapy efficacy through antigen-specific radiosensitization. The research focuses on delivering potent DNA damage...
- Federal Grant Award Summary Thomas Jefferson University (Sidney Kimmel Medical College) received a $484,405 Project Grant from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396) effective September 1, 2025, through August 31, 2030. This five-year award supports fundamental cancer biology research investigating NSD2 (Nuclear Set Domain Family Member 2) mutations and their role in driving acute lymphoblastic leukemia (ALL) transformation. The research...
- Federal Grant Award Summary The National Cancer Institute awarded The Johns Hopkins University a $510,431 Project Grant under the Cancer Biology Research program (CFDA 93.396) effective July 1, 2025 through June 30, 2030. This award supports fundamental research investigating the mechanisms of metastatic recurrence and therapeutic resistance in melanoma, with particular emphasis on understanding how aging influences tumor dormancy and the microenvironment. The research examines Wnt signaling...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded Johns Hopkins University a project grant of $109,076 under the Cancer Research Manpower program (CFDA 93.398) on January 16, 2026, with a completion date of July 31, 2028. This award funds research investigating the role of acetyl-coenzyme A synthetase 2 (ACSS2) in T cell adaptation to metabolic stress within tumor microenvironments. The research addresses a critical gap in understanding how T cells survive and...
Grant Award Summary The Johns Hopkins University received a $155,479 Project Grant from the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395) effective June 1, 2026 through May 31, 2028. The award supports the development and preclinical validation of an anti-CCRL2 (C-C motif receptor-like 2) antibody-drug conjugate (ADC) targeting high-risk myelodysplastic syndrome (MDS) and MDS-related acute myeloid leukemia (AML) patients with TP53 mutations or deletions. The research deliverables include conducting patient-derived xenograft studies, evaluating efficacy and safety in immunocompetent TP53-mutated syngeneic AML models, and validating the synergistic effects of combining the anti-CCRL2 ADC with PARP1/2 inhibitors (talazoparib and stenoparib) through in vitro and in vivo studies. This project addresses a critical clinical need in treating myeloid neoplasms with loss-of-function TP53 mutations, which currently have very short overall survival rates due to limited effective and safe therapeutic options. The preclinical research is designed to generate the evidence base necessary to transition the anti-CCRL2 ADC candidate to early-phase clinical trials, with anticipated findings providing validation of anti-leukemic activity, safety profile, and optimal combination therapy strategies for this high-risk patient population.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $155.5k | 5/26/26 |