Project Grant R03AI196368
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Icahn School of Medicine at Mount Sinai a Project Grant totaling $843,182.00 under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective April 16, 2026, with a completion date of March 31, 2031. This research initiative, titled "Determinants of Viral Assembly and Infectivity Within the Ebola Virus VP24 Protein," supports investigator-initiated biomedical research...
- Federal Project Grant Award Summary Mayo Clinic received a $441,100 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective August 1, 2025, through July 31, 2027. The award supports research focused on developing in vivo Ebola virus (EBOV) life cycle modeling systems under biosafety level-2 (BSL-2) conditions. The research objectives include generating two murine models to...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Icahn School of Medicine at Mount Sinai a Project Grant of $104,276 under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct investigator-initiated biomedical research. The award was made on March 8, 2026, with a completion date of September 14, 2028. The research project, titled "Evaluating Differences in Innate Immune Response to Highly Pathogenic H5N1...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded $856,791 to the Icahn School of Medicine at Mount Sinai on September 12, 2025, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct investigator-initiated research investigating the role of ANKEF1 (ankyrin repeat and EF-hand domain containing gene 1) in ciliary function and host defense against influenza virus infection. The research addresses the...
- Federal Project Grant Award Summary Boston University Medical Campus received a $449,625 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective September 11, 2025, through May 31, 2027. The grant supports structural biology research on filoviruses, specifically examining the virion, nucleocapsid, and inclusion body structures of Lloviu virus (LLOV) and Ebola virus (EBOV). The...
- Federal Grant Award Summary The University of Pennsylvania received a $446,875 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective September 16, 2025 through August 31, 2027. This award supports investigator-initiated biomedical research examining the nuclear localization and functional mechanisms of the Ebola virus VP40 protein. The research investigates how the VP40 matrix...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Icahn School of Medicine at Mount Sinai a Project Grant of $101,396.00 under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective March 10, 2026, with completion expected by September 14, 2029. This research project investigates how hepatocytes and skeletal myocytes influence adaptive immune responses to messenger RNA (mRNA) therapeutics delivered via lipid...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Boston University Medical Campus a $204,375 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective April 1, 2026 through March 31, 2028. This award supports investigator-initiated research focused on elucidating the mechanisms of filovirus messenger ribonucleic acid (mRNA) translation, with emphasis on Ebola virus and other highly pathogenic...
- Federal Project Grant Award Summary Award Overview The National Institute of Allergy and Infectious Diseases (NIAID) awarded $797,735 to Icahn School of Medicine at Mount Sinai under the Allergy and Infectious Diseases Research program (CFDA 93.855) for a five-year project period (June 11, 2025 – May 31, 2030). This Project Grant funds basic and translational research aimed at decoding the cellular and molecular mechanisms of early-life immune responses and sterile inflammation, particularly...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded $464,750 to Icahn School of Medicine at Mount Sinai on July 7, 2025, under the Allergy and Infectious Diseases Research program (CFDA 93.855) for a two-year project completion period extending through June 30, 2027. The award supports research focused on understanding and modulating T cell plasticity, specifically the transdifferentiation of TH17 cells into regulatory T cells...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $183,875 Project Grant to Icahn School of Medicine at Mount Sinai under the Allergy and Infectious Diseases Research program (CFDA 93.855) for the period of May 1, 2026 through April 30, 2027. This pilot project aims to elucidate the role of DDX60L (a DEXD/H box family protein) in Ebola virus disease (EVD) through a combination of molecular biology research and experimental modeling. The research deliverables include comprehensive studies utilizing small interfering RNA (siRNA) knockdown and CRISPR-Cas9-based approaches to define the mechanisms by which DDX60L exerts anti-Ebola virus (EBOV) effects and influences virus replication and interferon responses. The project employs three complementary experimental systems to deliver research products: transfection-based EBOV replication cycle modeling assays, studies using recombinant EBOV with GFP-tagged VP30 coding sequences (EBOV-GFPDVP30) at reduced biocontainment levels, and assays using fully replication-competent EBOV. Experimentation is conducted across cell lines representative of in vivo EBOV infection—hepatocyte (HUH7), epithelial (A549), and monocyte/macrophage (THP-1) cell lines—with assessments performed both with and without interferon alpha (IFNA) treatment. Deliverables include quantitative measurements of viral RNA synthesis, viral protein production, and host interferon responses, which collectively elucidate DDX60L's role as a negative regulator of EBOV infection and identify potential therapeutic strategies to mitigate EVD.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $183.9k | 4/28/26 |