Project Grant R21AI193179
- This Project Grant award of $480,249.00 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855). The grant supports research to investigate the role of the extracellular matrix (ECM) as a determinant of infectivity for the filoviruses Ebola (EBOV) and Marburg (MARV). The research aims to understand how ECM composition and stiffness impact the ability of these deadly viruses to...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $441,100 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the Mayo Clinic to develop mouse models for studying the life cycle of the Ebola virus (EBOV) under Biosafety Level-2 (BSL-2) conditions. The grant, with a performance period from August 2025 to July 2027, aims to generate two approaches for in vivo EBOV life cycle modeling using virus-like particles and expression of...
- This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $156,980.00 to the Icahn School of Medicine at Mount Sinai to study the functional significance and mechanisms of Ebola virus VP24 protein interactions with host proteins. The research aims to characterize the two binding modes of VP24 - those that are dependent on the host importin-alpha (IMPA) protein and those that are independent...
- The University of Iowa was awarded a $124,972 Project Grant by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant will support research to evaluate the impact of malaria on the immune response to the Ebola virus vaccine ERVEBO. Utilizing experimental Plasmodium infection models and clinically relevant vaccine administration strategies in mice, the research aims to understand how malaria infection...
- The University of Pennsylvania received a $891,410 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct research on therapeutic vaccination strategies to boost autologous neutralizing antibodies for ART-free HIV control. The award is focused on testing whether individualized mRNA-LNP delivered Env immunogens can enhance baseline autologous neutralizing antibody responses...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $466,125 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to New York University School of Medicine. The grant will support research to elucidate the molecular process of orthopox virus entry, including the MPXV and VACV viruses, through a comparative analysis using methods from virology, proteomics, and immunology. The research aims to identify and characterize the interactions...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $822,015 Project Grant titled "NOVEL STATISTICAL METHODS FOR CONFOUNDED AND INCOMPLETE NETWORK DATA" to the University of Pennsylvania. This grant, provided under the NIAID's Allergy and Infectious Diseases Research program (CFDA 93.855), will fund the development of new statistical methodologies to address challenges posed by missing data, confounding, and complex social network structures in studies of public...
- This federal Project Grant award, valued at $449,625.00 and provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), will support research to determine the morphology of the Lloviu virus (LLOV) virions and compare their structures to those of Ebola virus (EBOV) and Marburg virus (MARV). The research team will utilize cryogenic electron microscopy and tomography techniques to generate...
- This $221,105 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) is supporting research to investigate how poxviruses, such as monkeypox, can rapidly diversify their genomes to overcome host immune defenses. The research aims to advance understanding of the mechanisms by which host APOBEC enzymes can both restrict and promote viral evolution, with the goal of informing strategies to...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $859,992 Project Grant to Yale University for the "Molecular Investigations of HIV-1 Maturation Pathways and Inhibitor Actions in situ" research project. The grant, funded under NIAID's Allergy and Infectious Diseases Research Program (CFDA 93.855), aims to use advanced in-situ cryo-electron microscopy and tomography techniques to visualize the structural transitions of the HIV-1 virus during the maturation...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $446,875 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The Trustees of the University of Pennsylvania, doing business as Clinical Practices of the University of Pennsylvania. The grant supports research on the nuclear localization and function of the Ebola virus VP40 protein, a critical area for developing novel antiviral countermeasures against Ebola and Marburg viruses. The project aims to investigate how the VP40 protein interacts with the host protein YAP and "hitchhikes" into the cell nucleus, which may play a role in Ebola's impact on cellular processes like proliferation and epithelial-mesenchymal transition. The award period runs from Sep 16, 2025 to Aug 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $446.9k | 9/15/25 |