This $606,609 Cooperative Agreement award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research at the University of California, San Diego (UCSD) to develop T cell alloreactivity and organ transplant risk stratification models using high-resolution HLA and genomic data. The research aims to advance understanding of immune system responses and improve clinical outcomes for organ transplant recipients. The 5-year...
This Project Grant award, valued at $219,792.00, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855). The award, with a performance period from March 2025 to February 2027, supports the development of statistical methods to analyze high-throughput T-cell receptor sequencing (TCR-seq) data. The key objectives are to ensure that functional TCRs are not lost during data...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $3,194,992 to the University of California, San Diego (UC San Diego) to conduct research on the roles and regulation of tissue-resident CD8 T cells during a persistent viral infection. The key objectives are to: (1) evaluate the role of tissue-resident CD8 T cells in intestinal hyper-permeability and colitis during a sustained viral...
This Project Grant award of $405,497.00 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research to develop a compact viral system for robust, concurrent CRISPR activation and interference (CRISPRa/i) in primary murine immune cells. The goal is to use this system to map the gene regulatory network controlling BCL11B activation and T cell lineage commitment. Key innovations include CRISPR RNA-scaffolds to recruit...
This Project Grant award, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under CFDA Program 93.855 - Allergy and Infectious Diseases Research, will support research to investigate the genetic mechanisms that determine host susceptibility to low virulence strains of the Toxoplasma gondii parasite in mice. The $269,054 award, effective November 8, 2024 through October 31, 2026, will enable researchers at the University of California, Merced to leverage the...
This Project Grant award of $438,500 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research at the University of California, San Diego (UCSD) to investigate the mechanisms regulating immunoglobulin gene rearrangement. The research aims to determine how enhancers and epigenetic modifications orchestrate chromatin dynamics and spatial confinement to enrich interactions between variable...
This federal Project Grant award of $658,657, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research at the University of Virginia on the biophysical and functional coupling of protein condensates to ordered lipid domains in T-cells. The research aims to reveal the mechanisms by which protein condensates and membrane domains cooperatively regulate T-cell signal transduction and...
This Project Grant award, totaling $744,977.00, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant supports research at Emory University to explore the role of T cells in providing protection against respiratory virus transmission. Key objectives include defining the cellular interactions and molecular mechanisms of tissue-resident memory T cells (TRM) that can limit the spread of...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $3,022,197 to the University of California, San Diego (UCSD) to study the role of regulatory T (Treg) cells and the IL-27 cytokine in maintaining intestinal immune homeostasis. The research aims to examine the molecular mechanisms driving IL-27 expression in gut Treg cells, as well as identify gut microbiome factors...
The federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $972,151 to The Regents of the University of California, San Francisco (UCSF) to conduct systematic genetic investigations of the mechanisms governing immunogenic cell death (ICD). The project aims to enhance understanding of the molecular signals and cellular processes that determine whether phagocytes...