This $693,465 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), will support research by Cornell University to construct a molecular atlas of T cell development in lymph nodes and determine how cellular interactions and communication networks change during CD8+ T cell priming throughout childhood. The research aims to provide a new paradigm for understanding T cell activation and...
This federal Project Grant award for $857,346 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The funding supports research to define the balance of activating and inhibitory signals present in healthy and acutely infected human tissues, which is relevant for understanding how immune quiescence is achieved while also maintaining immune responsiveness. The primary awardee is the Fred...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $658,657 to support research aimed at understanding the biophysical mechanisms by which protein condensates functionally couple with ordered lipid domains in T-cells. The primary awardee, the University of Virginia, will conduct an integrated investigation spanning biophysical characterization, live-cell...
This federal Project Grant award of $534,000.00 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to investigate how antigen location and peptide-MHC class II (pMHCII) complex density and half-life can drive CD4+ T cell differentiation and functionality. The research, conducted by the Children's Hospital of Philadelphia (CHOP), aims to test a model proposing that extracellular...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), is providing $162,512 to the Regents of the University of Minnesota to investigate the factors that support the expansion and function of long-lived effector CD8 T cells within the memory compartment. The key objectives are to determine what pro-inflammatory cytokines and other factors promote the formation and...
This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research to examine the impact of maternal inflammation and viral infection during pregnancy on the development and function of fetal innate-like gamma-delta (γδ) T cells. The $783,611.06 award to the University of Vermont & State Agricultural College will fund a comprehensive research...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $479,204 to the University of Maryland, Baltimore to conduct research on parasite variant surface antigens and their role in severe malaria. The research aims to identify parasite genes associated with severe disease, which could inform vaccine and drug development. Key aspects include: Sequencing variant surface antigen transcripts...
This federal Project Grant award of $114,976, awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), will support research to elucidate the protective function of T cells in breastmilk against infant respiratory infections. The award recipient, Seattle Children's Research Institute, will investigate the respiratory-mammary axis of cellular immunity and the role of tissue resident memory T cells...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $545,686 to The Washington University to conduct research on the role of T cells and the cytokine interleukin-9 (IL-9) at the maternal-fetal interface in preterm labor and birth. The project aims to elucidate the mechanisms by which IL-9 promotes preterm labor and birth, define the impact of maternal IL-9 on fetal...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research on how T cell receptor (TCR) activation and T cell memory responses influence the development of sepsis and associated organ dysfunction, particularly in neonates and pediatric patients. The award, totaling $418,750.00 and running from January 1, 2025 to November 30, 2029, aims to characterize the dysregulated interactions...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 Allergy and Infectious Diseases Research) provides $178,932 to the University of Maryland, Baltimore to analyze cord blood Vγ9Vδ2 (Vδ2) T cell differentiation and function using cutting-edge single-cell approaches.
The award aims to investigate the significance of the inhibitory receptor PD1 in regulating Vδ2 T cell development and antimicrobial activity in early life. Utilizing Cellular Indexing of Transcriptomes and Epitopes by Sequencing (CITE-seq) and Assay for Transposase-Accessible Chromatin with Sequencing (ATAC-seq) techniques, the researchers will assess the transcriptional profiles and chromatin accessibility of sorted PD1+ and PD1- Vδ2 T cell subsets from cord blood samples. This research is expected to advance the understanding of Vδ2 T cell function in infants and inform future studies on the impact of maternal conditions, such as placental malaria, on Vδ2 T cells as potential biomarkers of disease risk in early life.
The project involves a sub-award to Weill Medical College of Cornell University to support the specialized single-cell analyses.