Project Grant R03AG095992
- This federal Project Grant award of $441,612 from the National Institute on Aging (CFDA 93.866 - Aging Research) to Trustees of Boston University (Boston University Medical Campus) supports research to evaluate the use of digital cognitive measures, such as digital pen tasks and voice recordings, to monitor early cognitive decline in relation to modifiable Alzheimer's disease risk factors. The project aims to leverage the Framingham Heart Study's longitudinal data on digital cognitive...
- The National Institute on Aging (NIA), under the Aging Research Federal Grant Program (CFDA 93.866), awarded a $129,330 Project Grant to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to conduct research on profiling and forecasting individual progression in Alzheimer's disease and related dementias (ADRD). The key objectives of this 5-year project are to: 1) deploy a multi-modal information framework that leverages decades-long in vivo and digital...
- This federal Project Grant award of $372,690, provided by the National Institute on Aging (CFDA 93.866 Aging Research), aims to comprehensively understand the heterogeneous causal pathophysiology of Alzheimer's disease (AD). The key objectives are to: (1) develop new statistical methods for uncovering heterogeneous causal relationships among amyloid-beta, tau accumulation, and cognition across diverse AD datasets; (2) apply these methods to reveal optimal treatment windows and target populations...
- This federal Project Grant award of $307,000.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to conduct a single, highly powered study to identify memory processes that are most sensitive to the asymptomatic, preclinical stage of Alzheimer's disease (AD) pathology. The study combines a continuous report item-location associative memory task with advanced behavioral and neural modeling to estimate subtle changes in memory precision that may differentiate healthy...
- This Project Grant award from the National Institutes of Health's Aging Research program (CFDA 93.866) will support research to identify early transcriptional and pathological changes in brain regions vulnerable to Alzheimer's disease (AD). The $459,076 award, granted to Trustees of Boston University, will use single-nucleus RNA sequencing and targeted mass spectrometry to profile cell type-specific gene expression and tau/amyloid beta proteoforms in the transentorhinal cortex, entorhinal...
- This federal Project Grant award for $366,648.00 was provided by the National Institute on Aging (NIA), under the Aging Research Federal Grant Program (CFDA 93.866), to New York University (NYU). The funding supports the development of statistical methods for improving estimation and prediction models related to Alzheimer's disease (AD) progression, leveraging data from longitudinal cohort studies. Specifically, the project aims to address challenges posed by complex truncation and censoring...
- This Project Grant award of $4,787,820.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to gain a better understanding of the individual- and system-level characteristics that influence diagnosis of mild cognitive impairment (MCI) and Alzheimer's disease and related dementias (ADRD), and how diagnosis can moderate the effects of cognitive decline on employment, future care, and quality of life. The key objectives are to: 1) examine whether older adults experiencing...
- The National Institute on Aging (NIA), through its Aging Research federal grant program (CFDA 93.866), awarded a $636,342 Project Grant to Trustees of Boston University (doing business as Boston University Medical Campus) to conduct research on normal and pathological brain aging. The grant, with a performance period from August 1, 2025 to April 30, 2030, will support a multiscale modeling and empirical study of progressive myelin dystrophy, loss of synapses, and neuronal hyperexcitability in...
- The National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), awarded a $131,813 Project Grant to the Trustees of Boston University (Boston University Medical Campus) on May 1, 2025. The grant aims to evaluate the effects of poverty alleviation policies, such as the Supplemental Nutrition Assistance Program (SNAP), on the risk and disparities of Alzheimer's disease and related dementias (AD/ADRD). The research will leverage data from the Health and...
- This federal Project Grant award of $3,188,901.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to better understand the relationships between in-vivo biomarkers for amyloid, tau, and neurodegeneration (ATN), neuropsychiatric symptoms, vascular risk factors, and genetic risks in Alzheimer's disease. The study will leverage data from large research cohorts like the Alzheimer's Disease Neuroimaging Initiative to develop and optimize machine learning models that can...
This federal Project Grant award of $327,000.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to leverage multimodal data, including traditional neuropsychological tests and digital voice recordings, to identify preclinical cognitive trajectories related to Alzheimer's disease. The project, titled "Exploring Heterogeneity of Cognitive Trajectories of Preclinical Alzheimer's Disease with Digital Phenotyping," will build a comprehensive model of cognitive progression by integrating clinical risk factors and utilizing the longitudinal dataset from the Framingham Heart Study. The goal is to enable the creation of individualized interventions and healthcare strategies for Alzheimer's disease by accurately characterizing cognitive function changes and identifying clinically relevant subtypes. The award was made to the Trustees of Boston University, doing business as the Boston University Medical Campus, a prominent private research institution with extensive experience in federal contract and grant work.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $327.0k | 9/4/25 |