Project Grant R03AG095761
- The National Institute of Environmental Health Sciences awarded the University of New Mexico Health Sciences Center $419,375 under the Environmental Health program (CFDA 93.113) on August 10, 2026, to explore nanoplastics' neurological effects through investigation of lipid mechanisms and glial inflammation. The recipient will conduct research on micro- and nanoplastics bioaccumulation in the human brain and their molecular interactions within cerebrospinal fluid and the central nervous...
- The National Institute of Environmental Health Sciences awarded Arizona State University $430,625 on May 15, 2026, under the Environmental Health program (CFDA 93.113) to conduct a multimethod study of micro- and nanoplastics in human brain tissue and their association with Alzheimer's disease and environmental disadvantage. The research quantifies micro- and nanoplastics in the olfactory bulb and middle temporal gyrus of 140 postmortem human brains (70 with Alzheimer's disease pathology, 70...
- The federal Project Grant award titled "Mechanisms of Nano Plastic Transport in the Brain" was provided by the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health Federal Grant Program (CFDA 93.113). The $404,989 grant, awarded on January 15, 2025, will fund research at The Pennsylvania State University (Penn State) to investigate how nanoplastics (plastic particles smaller than one micron) may be transported into the brain via the olfactory...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded Rutgers, The State University $573,035 on February 15, 2026, under the Aging Research program (CFDA 93.866) to investigate the control of cerebrospinal fluid hydrodynamics and brain-waste clearance mechanisms. The research examines how the glymphatic system facilitates the clearance of neurotoxic proteins such as amyloid-beta and tau, which accumulate in aging and neurodegenerative diseases including...
- The National Institute on Aging awarded the Regents of the University of Michigan $284,108 on January 1, 2026, under the Aging Research program (CFDA 93.866) to investigate how mechanical changes in the aging brain affect microglial function and Alzheimer's disease progression. The project explores the relationship between age-related mechanical alterations in brain tissue—specifically decreased stiffness and increased viscoelasticity resulting from reduced tissue connectivity—and microglial...
- The National Institute on Aging awarded The Trustees of Columbia University in the City of New York $691,683 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate the glymphatic system's role in perioperative neurocognitive disorder. The research characterizes how anesthesia and surgery impair glymphatic function—the brain's perivascular clearance pathway for neurotoxic proteins including beta-amyloid and phosphorylated tau—particularly in aging and Alzheimer's...
- The National Institute on Aging awarded Case Western Reserve University $3,153,437 on August 1, 2026, under the Aging Research program (CFDA 93.866) to develop and validate novel MRI methods for quantitative assessment of glymphatic function in the aging brain. The project will develop a three-dimensional magnetic resonance fingerprinting technique for dynamic, simultaneous tracking of oxygen-17 enriched water as a cerebrospinal fluid tracer and gadolinium-based contrast agents to measure...
- The National Institute on Aging awarded The General Hospital Corporation (doing business as Massachusetts General Hospital) $2,139,309 for a Project Grant (R01AG094755) on April 15, 2026, under the Aging Research program (CFDA 93.866). The recipient will develop advanced high-resolution MRI methods to noninvasively track cerebrospinal fluid flow and soluble amyloid-beta diffusion through perivascular spaces in the brain. The project tests three specific aims: developing and optimizing novel MR...
- The National Institute of Neurological Disorders and Stroke awarded the University of Arizona $102,368 on June 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to characterize the brain's lymphatic drainage in an Alzheimer's disease rat model and investigate two therapies—manual lymphatic drainage and lymphaticovenous anastomosis—for repurposing to Alzheimer's disease treatment. The research addresses an unmet need in...
- The National Science Foundation Division of Chemical, Bioengineering, Environmental, and Transport Systems awarded $199,991 to the Regents of the University of Michigan (doing business as University of Michigan-Dearborn) on May 15, 2026, under the Engineering Research Initiation program to design and build a microphysiological system that models cerebrospinal fluid dynamics in the brain to investigate mechanisms of neurodegeneration in Alzheimer's disease, Parkinson's disease, and amyotrophic...
The National Institute on Aging awarded the University of New Mexico Health Sciences Center a project grant of $305,000 on September 1, 2026, to study micro(nano)plastic accumulation in the central nervous system and its effects on cerebrospinal fluid-mediated waste removal. The research advances quantification methods for micro(nano)plastics in human cerebrospinal fluid using state-of-the-art microscopy and spectroscopy techniques, and evaluates how plastic accumulation in the central nervous system disrupts the glymphatic system's ability to clear waste products from brain tissue. Prior work by the team demonstrated that micro(nano)plastics accumulate in brain tissue at concentrations exceeding 0.5 percent of total brain weight, with accumulation elevated in dementia cases. The project assesses whether this accumulation impairs cerebrospinal fluid circulation and clearance of harmful substances such as amyloid-beta, which drive neurodegenerative disease progression. Work is performed in Albuquerque, New Mexico, with a period of performance from September 1, 2026, through August 31, 2028. The award is classified as a project grant under the Aging Research program (CFDA 93.866), which supports biomedical and behavioral research directed toward understanding aging and addressing Alzheimer's disease and related dementias.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $305.0k | 8/26/26 |