Project Grant R03AG095655
- This federal Project Grant award of $441,612 from the National Institute on Aging (CFDA 93.866 - Aging Research) to Trustees of Boston University (Boston University Medical Campus) supports research to evaluate the use of digital cognitive measures, such as digital pen tasks and voice recordings, to monitor early cognitive decline in relation to modifiable Alzheimer's disease risk factors. The project aims to leverage the Framingham Heart Study's longitudinal data on digital cognitive...
- This federal Project Grant award of $307,000.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to conduct a single, highly powered study to identify memory processes that are most sensitive to the asymptomatic, preclinical stage of Alzheimer's disease (AD) pathology. The study combines a continuous report item-location associative memory task with advanced behavioral and neural modeling to estimate subtle changes in memory precision that may differentiate healthy...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $499,686 to support the development of the Momento smartphone app. The app aims to transform regular photo activities into a way to continuously monitor cognitive function and detect early signs of memory changes in older adults. Key goals of the 1-year project include: 1) Testing how 200 older adults use and enjoy the app, ensuring it is engaging for regular use; and 2) Verifying the system can...
- This $114,498 Project Grant awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) will fund a study to investigate the construct validity of smartwatch-derived metrics for early detection of Alzheimer's disease and related dementias. The study will recruit a diverse sample of 90 participants aged 55 and older with healthy cognition or mild cognitive impairment from the Philadelphia region. Participants will wear a Garmin Vivosmart 4 smartwatch for 30 days to passively monitor...
- This $1,221,276 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports the "In Vivo Single-Cell Analysis of Alzheimer's Disease-Associated Regulatory Elements" research project at the University of North Carolina at Chapel Hill. The project aims to develop a novel genomic platform called Single-Cell Massively Parallel Reporter Assays (SCMPRA) to investigate how Alzheimer's disease-associated regulatory elements orchestrate gene expression...
- This $6,925,230 Project Grant award from the National Institutes of Health (NIH) National Institute on Aging (CFDA 93.866 - Aging Research) will support a research project at The Trustees of Columbia University in the City of New York to develop a "Multi-Organ Chart of Personalized Susceptibility to Alzheimer's Disease and Aging." The overarching goal is to use large-scale multi-omics, multi-organ biomedical data, advanced artificial intelligence/machine learning, and computational...
- The National Institute on Aging (NIA) awarded a $713,723.32 Project Grant under the Aging Research Federal Grant Program (CFDA 93.866) to the Albert Einstein College of Medicine in Bronx, NY. The award, effective from February 1, 2025 to January 31, 2028, will support research on the influence of neighborhood characteristics, both objective and subjective, as well as GPS-based personal activity space measures, on cognitive decline, Alzheimer's disease and related dementias (ADRD), and...
- This Project Grant award of $353,391.00, provided by the National Institute on Aging (CFDA 93.866 - Aging Research), aims to validate the use of a "Personal Learning Curve" paradigm as a sensitive marker of early memory decline related to Alzheimer's disease (AD) biomarkers in a large, diverse sample of older adults. The study seeks to determine if this digital cognitive assessment tool, which measures learning over repeated evaluations, can detect subtle AD-related memory failures...
- This federal Project Grant award for $2,557,260 from the National Institute on Aging (CFDA 93.866 Aging Research program) will fund a study titled "Lifecourse Predictors and Mechanisms of Early Clinical ADRD among Black and White Adults in their Sixties". The study aims to investigate the transition from midlife to early late-life and identify the earliest manifestations of Alzheimer's disease (AD) and Alzheimer's disease-related disorders (ADRD) in a diverse population. The research...
- This Project Grant award of $4,787,820.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to gain a better understanding of the individual- and system-level characteristics that influence diagnosis of mild cognitive impairment (MCI) and Alzheimer's disease and related dementias (ADRD), and how diagnosis can moderate the effects of cognitive decline on employment, future care, and quality of life. The key objectives are to: 1) examine whether older adults experiencing...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) aims to evaluate the utility of self-reported subjective cognitive concerns (SCC) as an early screening tool for Alzheimer's disease (AD). The $336,000 award will support research to: 1) assess the longitudinal relationship between baseline pen-and-paper measures of SCC and subsequent plasma AD biomarkers, 2) examine whether baseline smartphone-based ecological momentary assessment (EMA) SCC measures predict subsequent plasma AD biomarkers, and 3) apply machine learning to integrate pen-and-paper and EMA SCC assessments to improve the prediction of plasma AD biomarkers. This project will leverage the diverse older adult population of the Einstein Aging Study in the Bronx, NY to examine SCC assessment performance across different racial and ethnic groups. The award period is from Sep 1, 2025 to Aug 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $336.0k | 8/28/25 |