Project Grant R03AG094840
- The National Institute on Aging (NIA), part of the U.S. Department of Health and Human Services, awarded a $638,682 project grant under the Aging Research Federal Grant Program (CFDA 93.866) to the University of Arizona on August 1, 2025. The project, titled "TDP-43 LLPS and Mitochondrial Dysfunction in Neurodegeneration", aims to investigate the relationship between the liquid-liquid phase separation (LLPS) of the TDP-43 protein and mitochondrial dysfunction in neurodegenerative...
- The National Institute on Aging (NIA), through its Aging Research federal grant program (CFDA 93.866), awarded a $630,496 project grant to the J. David Gladstone Institutes to conduct research on proteostasis, neuroinflammation, and neurodegeneration in frontotemporal dementia (FTD). The research aims to better understand how GRN haploinsufficiency, a key genetic factor in FTD, impairs the autophagy/lysosomal pathway and ubiquitin proteasome system, leading to accumulation of toxic proteins,...
- This Project Grant award for $472,073, provided by the National Institute on Aging (CFDA 93.866 Aging Research), supports a research project at The Trustees of Columbia University in the City of New York to investigate the role of post-translational modifications, specifically sumoylation and succinylation, in the mitochondrial-nuclear communication mechanisms underlying tau toxicity in frontotemporal dementia (FTD). The project aims to elucidate how changes in these modifications influence...
- This Project Grant award from the National Institutes of Health (NIH), under the Aging Research program (CFDA 93.866), provides $610,836 to The Broad Institute, Inc. to conduct research on mitonuclear interactions in aging and neurodegenerative diseases like Alzheimer's. The project aims to leverage recent technological advances, including mitochondrial DNA editing and large-scale biobank analyses, to systematically investigate how mitonuclear interactions contribute to aging and...
- The National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), awarded a $404,058 project grant to the Regents of the University of Minnesota to support a novel approach to restore functional TDP43 for the treatment of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). The goal of the project is to identify small molecule compounds that can stabilize functional, multimerized forms of the TDP43 protein in order to restore its normal RNA...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $781,008.00 to investigate the role of tRNA modifications in regulating mitochondrial function and the mitochondrial proteome in Alzheimer's disease and related disorders (AD/ADRD). The research aims to identify genetic mutations in mitochondrial DNA, tRNA genes, and genes encoding the mitochondrial proteome that are associated with AD status, using large-scale whole genome sequencing data from...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $921,822 to Yale University to conduct research on the role of the TBK1 gene and its effects on lysosome function in neurodegenerative diseases like amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The research aims to elucidate the molecular mechanisms by which TBK1 coordinates lysosome function with cellular demand, including examining the contributions of TBK1...
- The National Institute on Aging (NIA) awarded a $157,998 Project Grant to The Medical University of South Carolina (MUSC) on July 17, 2025 under the Aging Research federal grant program (CFDA 93.866). The grant supports research to investigate the role of ceramides, a class of bioactive lipids, in regulating mitophagy (the recycling of damaged mitochondria) and its potential therapeutic applications for Alzheimer's disease. The research aims to elucidate the intricate mechanisms by which...
- This $3,360,074 federal Project Grant was awarded on September 15, 2025 by the National Institute on Aging (NIA) under the Aging Research grant program (CFDA 93.866). The grant is funding research led by the University of Pennsylvania to develop short RNA therapeutics that can combat TDP-43 proteinopathy, a key pathological feature of several devastating neurodegenerative disorders including Alzheimer's disease, amyotrophic lateral sclerosis, and frontotemporal dementia. The research aims to...
- This Project Grant award of $429,000 was provided by the National Institute on Aging (CFDA 93.866 - Aging Research) to the University of Texas Health Science Center at Houston to investigate the role of metal regulatory transcription factor-1 (MTF-1) in neurodegeneration and dementias. The research aims to determine if aberrant activation of MTF-1 is necessary and sufficient for driving neurodegeneration in fly models of Alzheimer's disease, tauopathies, and Lewy body dementia. It will also...
The National Institute on Aging (NIA) awarded a $310,083 Project Grant under the Aging Research federal grant program (CFDA 93.866) to the University of Arizona to investigate the role of the TMEM106B gene and mitochondrial dysfunction in frontotemporal lobar degeneration (FTLD) and other dementias. The research aims to determine if increased TMEM106B expression leads to changes in mitochondrial morphology, membrane potential, and respiration in cortical neurons, and to explore the mechanisms underlying TMEM106B-mediated mitochondrial dysfunction, focusing on its interaction with the sigma 1 receptor protein involved in regulating mitochondria-associated endoplasmic reticulum membranes. This 2-year project, running from September 1, 2025 to August 31, 2027, seeks to advance scientific understanding of the genetic and cellular factors contributing to neurodegenerative diseases like FTLD and Alzheimer's disease.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $310.1k | 8/26/25 |