This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to New York University School of Medicine provides $254,250 to develop a biologically relevant multi-scale model of brain aging using advanced diffusion MRI (dMRI) techniques. The goal is to create a brain microstructure age framework that provides insights into the processes underlying brain aging and Alzheimer's disease/related dementias (AD/ADRD). The award period runs from Sep 15, 2024 to Jun...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $2,415,422 to The General Hospital Corporation (doing business as Massachusetts General Hospital) to conduct research on neuroinflammation, perineural nets, and postoperative delirium. The award aims to investigate the role of the extracellular matrix and perineural nets in the pathogenesis of postoperative delirium, which is associated with increased risk of Alzheimer's disease and related...
This Project Grant from the National Institutes of Health's National Institute on Aging, under the Aging Research program (CFDA 93.866), provides $287,218.16 in funding to the University of Maryland, Baltimore from August 1, 2021 through March 27, 2022. The award supports research aimed at better understanding the impact of aging on muscle excitability and action potential conduction velocity. Specifically, the recipient will use electrophysiology techniques and optical imaging to examine...
The National Institute on Aging (NIA), under the Aging Research (CFDA 93.866) federal grant program, awarded a $461,313 Project Grant to Yale University to investigate the role of the protein CSPα in presynaptic autophagy and its implications for neurodegenerative diseases. The key objectives are to: 1) characterize synaptic vesicles, autophagosomes, and related proteins in wild-type and CSPα knockout mouse brains using mass spectrometry and electron microscopy; and 2) examine the relationship...
The National Institute on Aging (NIA) awarded a $1,055,313 Project Grant under the Aging Research (CFDA 93.866) federal grant program to the University of Miami. The grant will fund research to investigate how the glial ion channel CLH-1 controls organismal aging in the model organism C. elegans. The key objectives are to establish the function of glial CLH-1 that influences aging and identify the tissues and pathways regulated by glial CLH-1 in the aging process. This exploratory research is...
This Project Grant award from the National Institute on Aging's Aging Research federal grant program (CFDA 93.866) provides $871,419 to the University of Washington to conduct research on the role of microglia, the brain's immune cells, in the pathogenesis of Alzheimer's disease. The research aims to characterize molecular profiles and spatial organization of microglia across the adult age spectrum, both with and without Alzheimer's disease, through single-nucleus RNA sequencing of over 5,000...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the Sloan-Kettering Institute for Cancer Research in New York aims to understand the cellular mechanisms that regulate lymph node maintenance and atrophy during aging. The $513,957 award will support research to investigate the role of lymphatic endothelial cell NF-κB signaling in adult lymph node homeostasis. Key objectives include determining the effects of aging on lymph node lymphatic...
This $1,394,250 federal Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research program) supports research to identify common molecular mechanisms associated with pathological aging in the brain and adipose tissues, and the inter-organ communication that may contribute to age-related neurological and metabolic disorders. The award to the Icahn School of Medicine at Mount Sinai will fund a 2-year research project to: 1) Analyze tissue transcriptomes to distinguish...
The National Institute on Aging (NIA) awarded The Leland Stanford Junior University (Stanford University) a $428,563 Project Grant under the Aging Research Program (CFDA 93.866) to develop a modular cell-on-chip platform to study how neuronal activity regulates myelin sheath formation and how these dynamics are altered in neurodegenerative disease. The 2-year project will enable fine-tuning of neuronal stimulation, recording of extracellular activity, and high-resolution imaging of myelin...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will provide $203,278 to Brandeis University to conduct research on the neurobiological mechanisms underlying daily life activity participation in older adults and its relationship to Alzheimer's disease pathology. The research will use behavioral, psychophysiological, neuroimaging, and naturalistic approaches to understand age-related shifts in motivation and neuromodulation that impact older...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research to study age-related changes in the axo-glial interface, the interaction between nerve cells (axons) and their supporting glial cells, in the peripheral nervous system. The $401,425 award to Albany Medical College, a private non-profit medical school, will enable the establishment of a proteomic profile of the molecular signals involved when aged Schwann cells, the glial cells of the peripheral nervous system, fail to effectively re-engage and remyelinate demyelinated axons. This research aims to provide new insights into the mechanisms underlying the decline in peripheral nerve regenerative capacity during normal aging, which could inform future efforts to modulate axon-glia interactions and improve nerve recovery in older individuals.